Lithiumbis(trimethylsilyl)amide

Skin irritation / corrosion

Administrative data

Endpoint:

skin corrosion: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1999-08-02 to 1999-08-09

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliant study

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Lithiumbis(trimethylsilyl)amide

EC Number:

223-725-6

EC Name:

Lithiumbis(trimethylsilyl)amide

Cas Number:

4039-32-1

Molecular formula:

C6H19NSi2.Li

IUPAC Name:

lithium 1,1,1,3,3,3 hexamethyldisilazan-2-ide

Constituent 2

Reference substance name:

lithium hexamethyldisilazide

IUPAC Name:

lithium hexamethyldisilazide

Test animals

Species:

other: n.a.

Strain:

other: n.a.

Details on test animals or test system and environmental conditions:

Not indicated; in vitro test;

Test system

Type of coverage:

other: n.a.

Preparation of test site:

other: n.a.

Vehicle:

other: n.a.

Controls:

no

Amount / concentration applied:

not indicated

Duration of treatment / exposure:

not indicated

Observation period:

not indicated

Number of animals:

not indicated

Details on study design:

The international Corrositex assay kit is an in vitro method for determining the corrosive potential of chemical substances. The results of this assay were used to determine the United Nations Transport Regulations Packaging Group. For detailed test procedure see Sect. "Any other information on materials and methods incl. tables"

Results and discussion

In vivo

Irritant / corrosive response data:

The results of the categorization screen indicated that the test article, Lithium hexamethyldisilazide, fell into category 2. For further Information, see Sect. "Remarks on results incl. tables and figures"

Other effects:

none

Any other information on results incl. tables

One run has been performed:

Vial	1	2	3	4
Breakthrough time (h:min:sec)	00:18:10	00:17:25	00:17:39	00:1856
Mean	00:18:02

According to the results of the Corrositex TM Assay, the test article, Lithium hexamethyldisilazide, has to be classified as corrosive and allocated to packing group II according to the UN Dangerous Goods Transport Regulations.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: other: UN Dangerous Goods Transport Regulations

Conclusions:

Lithium hexamethyldisilazide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium hexamethyldisilazide was found to be corrosive and assigned to packing group II. Lithium hexamethyldisilazide has to be classified as corrosive Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC.

Executive summary:

In accordance with column 2 of REACH Regulation 1907/2006/EC Annex VII section 8.1 in-vitro studies for skin corrosion and skin irritation do not need to be conducted if the available information indicates that the criteria are met for classification as corrosive to the skin or the substance is flammable in air at room temperature. Lithium hexamethyldisilazide would react violently upon contact with water or air humidity, releasing corrosive lithium hydroxide, and likely starting to burn.

Lithium hexamethyldisilazide was tested for corrosive properties in the Corrositex TM Assay in a single trial (four replicates) to determine the packing group and the mean break through time. Lithium hexamethyldisilazide was found to be corrosive and assigned to packing group II.

Based on this data and as lithium hexamethyldisilazide reacts violently with water / air humidity to form lithium hydroxide, this substance is also found to be

- corrosive: Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and

- corrosive (R34) according to Directive 67/548/EEC.