Registration Dossier
Registration Dossier
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EC number: 233-126-1 | CAS number: 10042-59-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI.
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Industrial Hygiene Journal 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-propylheptan-1-ol
- EC Number:
- 233-126-1
- EC Name:
- 2-propylheptan-1-ol
- Cas Number:
- 10042-59-8
- Molecular formula:
- C10H22O
- IUPAC Name:
- 2-propylheptan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-propylheptanol
- Analytical purity: not stated
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted sample or solutions in water or propylene glycol
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- SCORING SYSTEM: Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: degree of corneal necrosis
- Time point:
- other: no data available
- Score:
- 2
- Max. score:
- 10
Any other information on results incl. tables
The primary eye irritation was graded as 2.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
