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EC number: 236-921-1 | CAS number: 13548-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summarized in this publication without detailed information, contributing to assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Differential toxicity and clearance kinetics of chromium(III) or (VI) in mice.
- Author:
- Bryson WG, Goodall CM (1983)
- Year:
- 1 983
- Bibliographic source:
- Carcinogenesis, 4:1535–1539.
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- chromium nitrate
- IUPAC Name:
- chromium nitrate
- Test material form:
- not specified
- Details on test material:
- These solutions were sufficiently concentrated to maintain pH below 2.5 by hydrolysis and thus prevent the olation and oxolation reactions and subsequent polymerisation that can otherwise occur.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: NZC
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Mice were (CxO) Fl hybrids ( 9 NZC/BlGd x a NZO/BlGd) of both sexes and NZC males from the original Cancer Research Department colonies (21).
After weaning at age 4 weeks they were kept in polycarbonate cages29 x 18 x 13 cm) with untreated wood shavings as litter in a room thermostatted at 22 °C and supplied with positive pressure, humidified and filtered entilation.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- exposed mice to 6 dosage levels of Cr(NO3)3.9H2O, calculated LD50 10 days after interperitoneal injection
Male and female mice aged 5—6 months and averaging 40 g body weight were randomised into groups of 3, and group treatments then fixed by a further randomisation using Fisher and Yates tables (26). Treatments involved i.p. injections of equimolar solutions of chromium(III) (3.25 /µg/g mouse) given either once or at weekly intervals. Dosages corresponded to one-sixth of the distal LD50 per injection.
Mice treated once were killed at 3, 7 or 21 days after treatment, and those injected repeatedly were killed at 1 —4, 8, 10, 12 and 14 weeks. After 8 weeks
the injections were every 2 weeks instead of weekly. - Doses:
- 6 dose levels, detailed information is not available
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- Mice were weighed and examined weekly. Treatments began at age 5-6 months and at various times mice were killed under ether anaesthesia and the carcasses stored sealed in plastic bags.
- Statistics:
- utilising at least 5 dose levels and 4 mice per level, Statistical comparisons were by Student's t-test.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 39.1 mg/kg bw
- Based on:
- element
- Remarks:
- chromium(III)
- 95% CL:
- > 8.6 - < 36.9
- Remarks on result:
- other: for Cr(NO3)3 no LD50 was determined but an average of 39.1 mg/kg was reported as average chromium(III) sulphate and chromium trichloride.
- Sex:
- male/female
- Dose descriptor:
- other: distal median lethal dose
- Effect level:
- 17.8 mg/kg bw
- Based on:
- element
- Remarks:
- chromium(III)
- 95% CL:
- >= 8.6 - <= 36.9
- Remarks on result:
- other: for chromium trinitrate
- Mortality:
- No death
- Clinical signs:
- N/A
- Body weight:
- N/A
- Gross pathology:
- N/A
Applicant's summary and conclusion
- Conclusions:
- LD50 of chromium trinitrate for acute toxicity is concluded to be 17.8 mg chromium (III)/kg bw.
- Executive summary:
The acute toxicities of the chromium(III) nitrate after i.p. injection were determined in NZC male mice according to Weil's method. The distal LD5o 10 days after injection is calculated to be 17.8 (8.6 -36.9) mg chromium (III)/kg body weight, which were summarized in this report without detailed information.
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