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EC number: 221-882-5 | CAS number: 3268-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-07-22 to 1985-08-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 09 Oct 2017
- Deviations:
- yes
- Remarks:
- no anaesthetic used
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals; Office of Pesticide Programs, U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, November 1982; Section 81-4, Primary Eye Ir
- Version / remarks:
- adopted Nov 1982
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA: Health Effects Test Guidelines, Office of Toxic Substances, Office of Pesticides and Toxic Substances, United States Environmental Protection Agency, August 1982 Acute Exposure, Primary Eye Irritation
- Version / remarks:
- adopted Aug 1982
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(methylthio)propionaldehyde
- EC Number:
- 221-882-5
- EC Name:
- 3-(methylthio)propionaldehyde
- Cas Number:
- 3268-49-3
- Molecular formula:
- C4H8OS
- IUPAC Name:
- 3-(methylthio)propionaldehyde
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Source: Hazleton Dutchland, Inc., Denver, Pennsylvania, USA
- Age at study initiation: at least 8 weeks
- Acclimatisation period: 14 days
- Housing: Individually housed
- Diet: Lab Rabbit Chow HF (Purina #5326), ad libitum
- Water: automatic watering system (municipal water), ad libitum
Environmental conditions:
- Temperature: 60 - 70°F (16-21 °C)
- Humidity: 30-70%
- Light cycle: 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 21 days
Reading time points: 1, 24, 48 and 72 h, and 7, 14 and 21 days - Number of animals or in vitro replicates:
- 1
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Approximately 24 h after test item instillation the treated eye was rinsed to remove any residual test material.
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: Fluorescein dye was used to confirm presence or absence of corneal ulceration in the treated eye starting with the 24 hour observation and at each subsequent observation until there was no stain retention for two observations.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Moderate to severe conjunctival redness (score 1-3) was observed within the first 72 hours post test item instillation and remained well-defined (score 2) on study Day 7. The effect was fully reversible until study Day 14. In addition, chemosis (score 1-2) was observed until study Day 14, but was reversible by study Day 21. Iritis (score 1) was observed within the first 72 hours after test item instillation, but the animal recovered from it thereafter. Extensive corneal opacification was seen one hour after dosing and persisted through Day 21. Pannus (neovascularisation of the cornea) occurred from Day 7 through 21, and a red mass (probability vascular in origin) on the cornea was seen on Day 14. Protrusion of the cornea considered indicative of intraocular pressure, was also seen on Day 7 and 21. The study authors mention that also necrosis was observed 48 and 72 hours and 7 days after test item instillation, but not at the the 14- and 21-day reading time point. In general necrosis is irreversibel, therefore it is unclear if the table in the study report is correct.
Any other information on results incl. tables
Irritation/corrosive response data at each reading time point up to removal of animal from the test
|
1h |
24h |
48h |
72h |
7d |
14d |
21d |
Mean (24h, 48h, 72h) |
Max. score: |
Conjunctivae |
1 |
2 |
3 |
3 |
2 |
0 |
0 |
2,67 |
3 |
Conjunctivae |
2 |
2 |
2 |
1 |
1 |
1 |
0 |
1,67 |
4 |
Iris |
+ |
1 |
1 |
1 |
0 |
0 |
0 |
1,00 |
2 |
Cornea |
3 |
2d,f |
3f |
3f |
3b,c,f |
4b,c,e,f |
3b |
2,67 |
4 |
*)At all scorings whole cornea (area score 4) affected
b: Pannus; c: Protruding cornea; d: Discharge tinted yellow; e: red mass (2x3 mm) on cornea; f: Observation confirmed with fluorescein
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Eye Damage 1, H318 according to Regulation (EC) No. 1272/2008.
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