Anisaldehyde

Specific investigations: other studies

Administrative data

Endpoint:

cytotoxicity

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically acceptable publication

Data source

Reference

Reference 1

Reference Type:

publication

Title:

An Evaluation of the Utility of Four in Vitro Short Term Tests for Predicting the Cytotoxicity of Individual Compounds Derived from Tobacco Smoke

Author:

Curvall M, Enzell CR and Pettersson B

Year:

1984

Bibliographic source:

Cell Biol Toxicol 1: 173 - 193

Reference 2

Reference Type:

publication

Title:

Effects of Tobacco and Tobacco Smoke Constituents on Cell Multiplication in Vitro

Author:

Pilotti A, Ancker K, Arrhenius E and Enzell C

Year:

1975

Bibliographic source:

Toxicology 5: 49 - 62

Reference 3

Reference Type:

publication

Title:

Effect of Tobacco Smoke Compounds on the Plasma Membrane of Cultured Human Lung Fibroblasts

Author:

Thelestam M, Curvall M and Enzell CR

Year:

1980

Bibliographic source:

Toxicology 15: 203 - 217

Reference 4

Reference Type:

publication

Title:

Effects of Tobacco Smoke Compounds on the Cilliary Activity of the Embryo Chicken Trachea in Vitro

Author:

Petterson B, Curvall M and Enzell CR

Year:

1982

Bibliographic source:

Toxicology 23: 41-55

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test substance cytotoxicity was accessed by evaluating its capacity to inhibit culture growth in ascites sarcoma BP8 cells, to inhibit of the oxidative metabolism in isolated brown fat cells, to increase the permeability of the membranes in human lung fibroblasts, or to increase the time to ciliostasis in the tracheas of unbom chickens.

GLP compliance:

no

Type of method:

in vitro

Endpoint addressed:

not applicable

Test material

Test material information

Constituent 1

Reference substance name:

Anisaldehyde

EC Number:

204-602-6

EC Name:

Anisaldehyde

Cas Number:

123-11-5

Molecular formula:

C8 H8 O2

IUPAC Name:

4-methoxybenzaldehyde

Details on test material:

- Name of test material (as cited in study report): p-anisaldehyde
No further details provided

Results and discussion

Any other information on results incl. tables

Cytotoxicity values for the test substance were obtained in four in vitro short term test systems. The mean activity of the results from the four test systems in a 10-point scale was determined as 0.8 (1 for cell growth inhibition in Ascites sarcoma BP 8 cells, 2 for inhibition of the oxidative metabolism in hamster brown fat cells, 0 for membrane damage of human diploid embryonic lung fibroblasts, 0 for inhibition of ciliary activity using chicken embryo trachea).