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Diss Factsheets
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EC number: 247-955-1 | CAS number: 26748-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Principles of method if other than guideline:
- After some preliminary observations the test material was given undiluted by gavage to groups of five males and five females in single doses. They were observed for signs of intoxication during a 14 days period, after which autopsies were carried out on the survivors.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl peroxyneodecanoate
- EC Number:
- 247-955-1
- EC Name:
- tert-butyl peroxyneodecanoate
- Cas Number:
- 26748-41-4
- Molecular formula:
- C14H28O3
- IUPAC Name:
- Reaction products of neodecanoic acid (or neodecanoyl chloride derived from neodecanoic acid) and tert-butyl hydroperoxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Institute`s colony
- Age at study initiation: young adults
- Weight at study initiation: males 243 to 321 g; females 140 to 220 g
- Fasting period before study: overnight
- Housing: in groups of five in screen-bottomed stainless steel cages
- Diet: stock diet ad libitum (after treatment)
- Water: tap water ad libitum (after treatment)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25 °C
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Maximum dose volume applied: 20 mL /kg bw
- Doses:
- 11.6, 13.9, 16.7 or 20.0 mL /kg bw
- No. of animals per sex per dose:
- 5 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was calculated according to the method of Weil (Biometrics 8 (1952) 249-263).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 12 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 10.2 - <= 14.4
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 10 776 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 mg/kg bw
- Based on:
- act. ingr.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 082 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Most of the deaths occurred between 21 hours and 8 hours after treatment. One female rat died after 13 days. After 8 days the animals who survived recovered gradually.
- Clinical signs:
- other: Within a few hours after treatment all rats showed sluggisness, humpback behavior and severe diarrhoea. Within a few days after treatment several rats showed irritation of the skin in the area arround anus and tailroot; encrustations around eyes and nostr
- Gross pathology:
- At the end of the observation period some of the rats still showed necrosis of the skin around anus and tailroot. No other treatment-related gross alterations were seen at autopsy.
Any other information on results incl. tables
The doses applied and the mortality figures are shown in the table below:
Dose mL/kg |
Mortality |
||
Males (number) |
Females (number) |
% |
|
11.6 |
3/5 |
1/5 |
40 |
13.9 |
3/5 |
3/5 |
60 |
16.7 |
5/5 |
4/5 |
90 |
20.0 |
5/5 |
3/5 |
80 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A LD50 value of 12.0 mL /kg bw (10776 mg/kg bw) for tert-butyl peroxyneodecanoate (75 % solution) was determined in this study and a LD50 value of 9 mL/kg bw (8082 mg/kg bw) was calculated for the pure t-butyl peroxyneodecanoate (actual ingredient). Therefore, the test substance was considered as practically non-toxic.
- Executive summary:
Tert-butyl peroxyneodecanoate (75 % solution) was given undiluted by gavage to groups of five males and five females in single doses of 11.6, 13.9, 16.7 or 20.0 mL/kg bw. They were observed for signs of intoxication during a 14 days period, after which autopsies were carried out on the survivors.
The LD50 of the test item was calculated in study to be 12.0 mL/kg bw (10776 mg/kg bw) with 10.2 and 14.4 as the 95 % confidence limits. a LD50 value of 9 mL/kg bw (8082 mg/kg bw) was calculated for the pure t-butyl peroxyneodecanoate (actual ingredient). Therefore, the material was considered practically non-toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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