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Diss Factsheets
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EC number: 208-778-5 | CAS number: 541-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. The study is sufficient for the evaluation of ethylchloroformate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : low volume of test article; does, however, not invalidate the result.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl chloroformate
- EC Number:
- 208-778-5
- EC Name:
- Ethyl chloroformate
- Cas Number:
- 541-41-3
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- ethyl chlorocarbonate
- Details on test material:
- - Name of test material (as cited in study report): Aethylchlorkohlensäureester (ethy carbonochloric acid ester)
- Substance type:
- Physical state: liquid
- Analytical purity: ca. 95 %
- internalTest substance No. XIX/351.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach, Germany
- Weight at study initiation: 2.0 kg (f), 2.0 kg (m), 3.0 kg (m)
- Housing: single
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.05 ml
- Duration of treatment / exposure:
- application ito the conjunctival sack, no washing afterwards
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done
SCORING SYSTEM:
Comparable to the draize scoring system
TOOL USED TO ASSESS SCORE: luorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 1.4
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Severe eye irritation and corneal opacity was seen at 1 h after application and persisted until the end of the observation period on day 8 after treatment.
Any other information on results incl. tables
Descriptive scores of the raw data have been converted to Draize numerical scores.
Animal |
Reading |
Opacity |
Iritis |
Redness |
Chemosis |
Comment |
1 |
1 h |
3 |
0 |
2 |
2 |
|
2 |
1 h |
1 |
0 |
2 |
3 |
|
3 |
1 h |
3 |
0 |
1 |
2 |
|
4 |
1h |
3 |
0 |
2 |
4 |
|
1 |
24 h |
3 |
0 |
2 |
2 |
hemorrhage |
2 |
24 h |
2 |
0 |
2 |
3 |
|
3 |
24 h |
3 |
0 |
1 |
3 |
|
4 |
24 h |
3 |
2 |
2 |
3 |
hemorrhage |
1 |
48 h |
2 |
2 |
2 |
2 |
hemorrhage |
2 |
48 h |
- |
- |
- |
- |
no data |
3 |
48 h |
- |
- |
- |
- |
no data |
4 |
48 h |
2 |
2 |
2 |
3 |
hemorrhage |
1 |
72 h |
2 |
2 |
2 |
3 |
hemorrhage |
2 |
72 h |
2 |
2 |
2 |
3 |
|
3 |
72 h |
3 |
2 |
1 |
3 |
|
4 |
72 h |
2 |
2 |
2 |
3 |
hemorrhage |
1 |
8 d |
3 |
2 |
2 |
1 |
staphyloma/suppuration |
2 |
8 d |
3 |
2 |
2 |
1 |
staphyloma/suppuration |
3 |
8 d |
3 |
2 |
2 |
1 |
staphyloma/suppuration |
4 |
8 d |
3 |
2 |
2 |
1 |
staphyloma/suppuration |
mean |
24 - 72 h |
2,4 |
1.4 |
1.7 |
2.80 |
|
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- The results indicate the risk of serious damage to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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