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Diss Factsheets
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EC number: 220-250-6 | CAS number: 2687-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- yes
Test material
- Reference substance name:
- 1-ethylpyrrolidin-2-one
- EC Number:
- 220-250-6
- EC Name:
- 1-ethylpyrrolidin-2-one
- Cas Number:
- 2687-91-4
- Molecular formula:
- C6H11NO
- IUPAC Name:
- 1-ethylpyrrolidin-2-one
- Details on test material:
- purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Only animals free from clinical signs of disease were used for the study. The females were nulliparous and non-pregnant. The animals were subjected to an acclimatization period of at least 1 week in which they were adapted to the surroundings. Age of the animals at the beginning of the study was approx . 8 - 10 weeks for males and approx. 11 - 13 weeks for females. The animals were identified individually numbered consecutively on the tail. The feed used in the study was assayed for chemical as well as for microbiological contaminants. The drinking water is regularly assayed for chemical contaminants by the municipal authorities as well as for the presence of microbes. The animals were kept in fully air-conditioned rooms in which temperatures in the range of 20 - 24°C and relative humidities in the range of 30 - 70% were regulated by means of a central air-conditioning system. The animals were housed singly in cages type DK III without bedding, with a light/dark cycle of 12 hours.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: The test substance was doses unchanged. A liquid aerosol was generated.
- Details on inhalation exposure:
- Considering the vapor pressure of the test substance, the test atmosphere was supposed to be a mixture of vapor and liquid aerosols.
After the exposure, the animals were observed for 14 days.
The body weight of the animals was determined just prior to exposure (day 0), weekly thereafter and at the end of the observation period. A check for overt clinical signs of toxicity or mortality as well as a check for the presence of feed and drinking water was made twice a day on workdays and once daily on weekends and public holidays. Detailed clinical observations were recorded for each animal separately several times during exposure and at least once on each workday of the observation period. At the end of the observation period the animals were sacrificed with CO2 and were subjected to gross-pathological examination. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.1 mg/l
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.1 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: aerosol
- Mortality:
- No mortality occurred at the tested concentration.
- Clinical signs:
- other: Clinical signs of toxicity comprised visually accelerated respiration, squatting posture, piloerection, smeared and contaminated fur. Findings were observed from hour 0 of exposure until including study day 1.
- Body weight:
- The mean body weights of the male and female animals did not increase adequately during the first post exposure observation week, but increased during the second week.
- Gross pathology:
- No gross pathological abnormalities were noted in the animals necropsied at termination of the post exposure observation period.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.