3-aminophenol

Toxicity to birds

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to birds: acute oral toxicity test

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer reviewed journal

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: As mention below

Principles of method if other than guideline:

Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol. LD50 values were calculated.

GLP compliance:

not specified

Dose method:

gavage

Analytical monitoring:

not specified

Vehicle:

yes

Details on preparation and analysis of diet:

Solutions or suspensions of the test chemical were prepared in propylene glycol

Test organisms (species):

other: Redwing blackbird (Agelaius phoeniceus)

Remarks:

Exposure duration not reported

No. of animals per sex per dose and/or stage:

no data

Control animals:

not specified

Reference substance (positive control):

not specified

Key result

Dose descriptor:

LD50

Effect level:

237 mg/kg bw

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Exposure duration not mentioned

Validity criteria fulfilled:

not specified

Conclusions:

The median lethal dose (LD50) value of the test chemical to Redwing blackbird (Agelaius phoeniceus) is determine to be 237 mg/kg.

Executive summary:

Aim of this study was to determine the effect of test chemical on the growth of Redwing blackbird (Agelaius phoeniceus). Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol. LD50 values were calculated. The median lethal dose (LD50) value of the test chemical to Redwing blackbird (Agelaius phoeniceus) is determine to be 237 mg/kg. Based on the results, test chemical is moderately toxic to birds via oral exposure.

Description of key information

Aim of this study was to determine the effect of test chemical on the growth of Redwing blackbird (Agelaius phoeniceus). Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol. LD50 values were calculated. The median lethal dose (LD50) value of the test chemical to Redwing blackbird (Agelaius phoeniceus) is determine to be 237 mg/kg. Based on the results, test chemical is moderately toxic to birds via oral exposure.

Key value for chemical safety assessment

Short-term EC50 or LC50 for birds:

237 mg/kg food

Additional information

Based on the various experimental data for the target chemical study have been reviewed to determine the mode of action of test chemical on the growth and other activity of birds. The studies are as mentioned below:

In the first experimental key study from peer reviewed journal 1983, toxicity was measured. Aim of this study was to determine the effect of test chemical on the growth of Redwing blackbird (Agelaius phoeniceus). Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol. LD50 values were calculated. The median lethal dose (LD50) value of the test chemical to Redwing blackbird (Agelaius phoeniceus) is determine to be 237 mg/kg. Based on the results, test chemical is moderately toxic to birds via oral exposure.

 

First study was supported by the second study from peer reviewed journal 1983. Study was conducted to determine the effect of test chemical on the growth of birds. Solutions or suspensions of the test chemical were prepared in propylene glycol. LD50 value of the test chemical to quail is determine to be 750 mg/kg. Based on the results, it was concluded that the test chemical is not toxic to birds via oral exposure.

 

Thus based on the both studies toxicity was ranges from 237 mg/l to 750 mg/l.