Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-646-3 | CAS number: 109-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study without detailed documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative mutagenicity of halogenated pyridines in the Salmonella typhimurium/mammalian microsome test
- Author:
- Claxton LD, Dearfield KL, Spanggord RJ, Riccio ES, & Mortelmans K
- Year:
- 1 987
- Bibliographic source:
- Mutation Research; 176:185-198
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- - missing strain TA 1535.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-chloropyridine
- EC Number:
- 203-646-3
- EC Name:
- 2-chloropyridine
- Cas Number:
- 109-09-1
- Molecular formula:
- C5H4ClN
- IUPAC Name:
- 2-chloropyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-Chloropyridine
- Analytical purity: 99.0%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: TA 97, TA 98, TA 100, and TA 102
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254-induced rat liver microsomes (S9)
- Test concentrations with justification for top dose:
- 0, 50, 100, 500, 1000, or 5000 (- S9) and 0, 50, 100, 500, 1000, 5000, or 7500 µg/plate (+ S9)
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- - DMSO
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: - publication states "appropriate ... positive controls were run in parallel with each assay".
- Details on test system and experimental conditions:
- Details provided in Ames et al., 1975
- Evaluation criteria:
- A chemical was not designated positive or negative unless reproducible results were obtained. A positive response was defined as a reproducible, dose-related increase in histidine independent revertants over the solvent control level in at least one strain/activation combination; it was not necessary for this increase to be equal or greater than 2-fold the background.
A definitive positive or negative result was assigned to a test result when the statistical methods and visual examination of the data agreed. An equivocal response occurred when (1) test results were not reproducible, (2) a low-level but no dose-related increase in histidine positive colonies was obtained, or (3) when an increase was observed at only one dose level. - Statistics:
- Publication states that "results were examined statistically by both the methods of Stead et al. (1981) and Bernstein et al. (1982)".
Results and discussion
Test results
- Species / strain:
- other: TA 97, TA 98, TA 100, and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- - only in the presence of S9 (doses of 5000 and 7500 µg/plate caused increases that were more than double the vehicle control level).
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- - publication states that "no toxicity was observed even when the applied concentration reached 7500 µg/plate."
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
positive with metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.