Registration Dossier
Registration Dossier
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EC number: 202-501-1 | CAS number: 96-34-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on the QSAR estimation using the OECD Toolbox v1.1, the substance is considered to be a skin sensitiser.
Furthermore, as published in an article, the analogue monochloro acetic acid ethyl ester (EMCA) was tested in the Guinea Pig Maximization Test (Magnusson and Kligman) to determine its possible sensitizing potential. EMCA showed the capacity to sensitize 5 of 20 guinea pigs. On day 49, cross-reaction patterns to the methyl ester of MCA (MMCA) were studied in four animals. All animals reacted to MMCA (5%-0.5%). EMCA is concluded to be a sensitizer to humans. Cross reactivity to MMCA may occur.
Migrated from Short description of key information:
Weight of evidence: Read across from results published in an article with the analogue monochloro acetic acid ethyl ester and QSAR estimation using the OECD Toolbox.
Justification for classification or non-classification
Based on the results observed on the analogue and the results based on QSAR estimations, the substance methyl chloroacetate is considered a skin sensitizer. According to the CLP Regulation, the substance is classified as Skin Sensitizer Category 1.
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