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EC number: 237-075-6 | CAS number: 13598-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, experimental study, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single acute oral administration of ammonium perrhenate was given to rats in a range-finding study at doses of up to 2000 mg/kg bw. A further (main) study was planned using the highest dose level causing no deaths in the range-finding study, however further samples of the test material were unavailable.
- GLP compliance:
- no
- Remarks:
- Conducted prior to requirement for GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ammonium perrhenate
- EC Number:
- 237-075-6
- EC Name:
- Ammonium perrhenate
- Cas Number:
- 13598-65-7
- Molecular formula:
- H4N.O4Re
- IUPAC Name:
- Ammonium oxido(trioxo)rhenium
- Details on test material:
- - Name of test material (as cited in study report): ammonium perrhenate
- Substance type: white crystalline solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent
- Age at study initiation: “young adult”
- Weight at study initiation: 175-240 g
- Fasting period before study: overnight fast
- Housing: 5 rats of one sex in polypropylene cages
- Diet: ad libitum oxoid maintenance diet supplied by Herbert C. Styles (Bewdley) Ltd
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): “thermostatically controlled room”
- Photoperiod (hrs dark / hrs light): “controlled lighting conditions”
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- The dose was administered by a single peroral injection using a metal cannula. The test material was dissolved in vegetable oil on a weight/volume basis to contain the required dose per kg bw in 10 ml of the vegetable oil.
- Doses:
- Male and female rats were administered 25, 50, 200, 500 or 2000 mg/kg bw.
- No. of animals per sex per dose:
- One rat/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: immediately after dosing, 4 hrs after dosing, and daily for 14 days.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths were reported within the 14 day observation period.
- Clinical signs:
- other: No overt signs of toxicity were reported within the 14 day observation period.
- Gross pathology:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of ammonium perrhenate in the rat was found, in a range-finding study, to be >2000 mg/kg bw.
- Executive summary:
In a range-finding study, one male and one female rat/group were administered 25, 50, 200, 500 or 2000 mg ammonium perrhenate/kg bw by stomach tube. No deaths were seen in either sex at any dose level. A further study was intended using groups of 5 male and 5 female rats and treating them at the highest dose level causing no deaths in the range-finding study (i.e. 2000 mg/kg bw). However, due to the unavailability of the test material, this was not possible.
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