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EC number: 219-154-7 | CAS number: 2374-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
2,4,6-Trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane (CAS 2374 -14 -3, F-D3) has an extremely low estimated water solubility of 1.3E-06 mg/l and very high estimated log Kow of 9.
The substance is susceptible to hydrolysis with a half-life of 6 days at pH 7 and 25°C, and while the reaction products (fluorinated siloxanediols) in principle have higher water solubility than F-D3, preliminary evidence from the long-term Daphnia test suggests that precipitation of insoluble oligomers occurs at loading rates above the solubility of the test substance (refer to IUCLID Sections 4 and 5.1.2 for further discussion on condensation of the silanol hydrolysis product). However, the registered substance has a high adsorption potential, and once adsorbed, hydrolysis may not occur.
Regarding approach to filling data gaps: These physicochemical properties indicate that maintaining stable aqueous test solutions will be extremely difficult (as confirmed by the attempted long-term study with Daphnia magna). Furthermore, the substance will have the tendency to adsorb onto the glassware under experimental conditions. This contributes to technical difficulties making reliable experimental studies very difficult to conduct.
Acute aquatic toxicity studies were not conducted due to the very low water solubility of the substance. However, a long-term Daphnia test performed at the limit of functional water solubility showed no acute effects.
In addition:
- Above a log Kow of 6.0 short-term toxicity effects are not expected to occur, because the very limited aqueous solubility prevents toxic concentrations being achieved in exposure media. Similarly, above log Kow of 8, long-term toxicity effects are not expected1.
Regarding environmental exposure: the chemical properties indicate the substance will have the tendency to adsorb onto dissolved organic matter in the natural environment. Therefore, aqueous exposure is unlikely.
In addition:
- The substance is classified for severe human health effects; therefore measures are in place to minimise exposure. These control measures to prevent human health exposure will also control environmental exposure.
- The physicochemical properties and very high value of Koc (6.0) means that if the substance were to enter a wastewater treatment plant in influent waste waters, it would partition mainly to sludges (a small proportion may be volatilised), with a negligible amount passing to water. The result is that exposure of freshwater or marine aquatic compartments is negligible.
Furthermore, the substance is not manufactured or used as such in the EU and is registered in accordance with the REACH Regulation (Article 6) in order to support import of polymers. Residual unbound monomer in polymer is very low and the substance is of extremely low water solubility, such that unintentional release to the aquatic environment from end use of the polymers is negligible.
1The very high log Kow(>7.5) and very low limit of solubility in water mean the substances have very low bioavailability. For substances with these properties, chronic aquatic ecotoxicity is unlikely to be of concern. The principle of log Kow-based cut-off values for toxic effects has been embraced by the ICCA and OECD high Production Volume (HPV) chemical programmes (e.g. UNEP, 2000). The US EPA has also accepted them in its Pollution Prevention Framework (http://www.epa.gov/oppt/p2framework/docs/casestu.htm). The ECOSAR QSAR applies a log Kowcut-off value of 8.0 beyond which chronic toxicity of neutral organics would not be expected because of limitations in bioavailability and uptake of the substance (Clements, 1996). These cut-offs are empirically derived and based on experimental test data.
References:
Clements (1996). Estimating toxicity of industrial chemicals to aquatic organisms using structure-activity relationships. Edited by: Richard G. Clements. Contributors: R.G. Clements, J.V. Nabholz, M. Zeeman, Environmental Effects Branch, Health and Environmental Review Division, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, DC 20460, August 30, 1996.
UNEP (2000). OECD SIDS Alfa Olefins(CAS N°:592-41-6, 111-66-0, 872-05-9,112-41-4, 1120-36-1).UNEP Publications.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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