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Diss Factsheets
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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well-documented report which meets basic scientific principles (72 hour reading time point is missing).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test: Two animals were treated for 1, 5, 15 min or 20 h using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 and 48 hours and at the end of the observation period (8 days).
- GLP compliance:
- no
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- tripropylamine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Tri-n-propylamine
- Physical state: liquid
- Analytical purity: >= 98 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.0 and 3.15 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animal served as control
- Duration of treatment / exposure:
- 1, 5, 15 min and 20 h
- Observation period:
- 24 h, 48 h, 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol (conc.) and Lutrol/water (1:1)
- Time after start of exposure: after the exposure time: 1, 5, 15 min
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 72 hour reading point missing, leathery necrosis after 8 days
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- Exposure to the substance for 15 minutes resulted in one animal in a leathery necrosis which was not reversible within 8 days. A 20-hour exposure resulted in both tested animals in leathery necrosis which was not reversible within 8 days.
Any other information on results incl. tables
Detailed results:
|
|
|
Duration of treatment |
|||
Animal |
Reading after |
|
1 min |
5 min |
15 min |
20 hours |
1 |
24 hours |
Erythema |
1 |
1 |
4 |
2 |
Edema |
0 |
1 |
2 |
2 |
||
other |
Spotted |
- |
|
Partly grey necrosis |
||
48 hours |
Erythema |
0 |
1 |
2 |
2 |
|
Edema |
0 |
1 |
1 |
2 |
||
other |
|
spotted |
|
Partly necrosis |
||
8 days |
Erythema |
0 |
0 |
0 |
0 |
|
Edema |
0 |
0 |
0 |
0 |
||
other |
|
Slight scaling |
marked scaling (parchmenty) |
Leathery necrosis, surrounding: slight scaling |
||
2 |
24 hours |
Erythema |
1 |
2 |
3 |
2 |
Edema |
1 |
2 |
2 |
3 |
||
Other |
|
|
|
Grey soft necrosis |
||
48 hours |
Erythema |
1 |
2 |
2 |
2 |
|
Edema |
0 |
2 |
1 |
3 |
||
Other |
spotted |
|
|
Partly parchmenty necrosis |
||
8 days |
Erythema |
0 |
0 |
0 |
0 |
|
Edema |
0 |
0 |
0 |
0 |
||
Other |
scaling |
marked scaling (parchmenty) |
Leathery necrosis |
Comprehensive leathery necrosis |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Exposure of skin of rabbits to tripropylamine for 15 minutes resulted in necrosis which was not reversible within 8 days.
- Executive summary:
The skin irritation potential of tripropylamine was determined in a test according to an internal BASF method. Two animals (Vienna White rabbits) were treated with the test substance for 1, 5, 15 min or 20 h using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the liquid test substance. After the application time the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 and 48 hours and at the end of the observation period (8 days). The 1 -min and 5 -min exposure of the animal skin to tripropylamine resulted in skin reactions which were fully reversible within 8 days. Exposure to the substance for 15 minutes resulted in one animal in a leathery necrosis which was not reversible within 8 days. A 20-hour exposure resulted in both tested animals in leathery necrosis which was not reversible within 8 days.
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