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EC number: 212-783-8 | CAS number: 868-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
STUDIES IN ANIMALS
Toxicokinetics
Information on toxicokinetics is available from one study where Fischer
344 rats and B6C3F1 mice were administered once orally 10 - 200 mg/kg
14C-labelled dimethyl phosphonate by gavage. Furthermore, rats were
treated repeatedly for 5 days with an oral dose of 200 mg/kg bw 14C
labelled dimethyl phosphonate
Absorption
From the studies on metabolism it can be concluded that dimethyl
phosphonate was readily and near completely absorbed from the
gastrointestinal tracts of rats and mice.
Distribution
Dimethyl phosphonate derived radioactivity was widely distributed in
tissues of rats and mice 24 h after dosing. The radioactivity in the
tissues was approximately proportional to the dose. The highest
concentrations were observed in liver, kidney, spleen, lungs, and
forestomach, and the lowest in brain, skeletal muscle, adipose tissue,
and testes. Concentration of dimethyl phosphonate derived radioactivity
in all tissues increased as the number of daily doses increased. The
pattern of tissue distribution in mice was similar to that observed in
rats but the radioactivity measured in mice tissues after the
administration of labeled dimethyl phosphonate was lower.
Elimination
In rats 49 - 57 % of radioactivity was recovered as expired air (nearly
complete after 12 hours), 28 - 38 % was found in urine (after 24 hours)
and 2.5 % as organic volatiles. In mice approximately 44 % of
radioactivity was eliminated via CO2 after 12 hours and approximately 49
% was found in urine after 24 hours. About 1 to 2 % of the radioactivity
was found in the faeces in both species. The rate, extent and pattern of
elimination of radioactivity were unaffected by dose over the range
studied and by repeated administration.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Dimethyl phosphonate administered at a range of dose of 10-200 mg/kg was readily and near completely absorbed from the gastrointestinal tracts of rats and mice. Dimethyl phosphonate was eliminated primarily as CO2 in the expired air, 44-57%, and urine 28-49%, and very little was collected in feces, 1-2%, or as volatile organics, 2-3%. Dimethyl phosphonate derived radioactivity was widely distributed in tissues of rats and mice, with the highest concentrations observed on the liver, kidneys, spleen, lungs and forestomach, and the lowest in brain, skeletal muscle, and adipose tissue. The disappearance of radioactivity from mouse tissues was approximately twice as rapid as from rat tissues. In vitro, dimethyl phosphonate was metabolized to formaldehyde by the microsomal fraction of liver, lungs, kidneys, forestomach, and glandular stomach. In vivo, dimethyl phosphonate was metabolized to the product of demethylation, monomethyl hydrogen phosphite (MMHP), which was excreted in urine.
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