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EC number: 230-939-3 | CAS number: 7378-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 6 June 1996 to 13 September 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: There are not desviations from the recommended guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl(octyl)amine
- EC Number:
- 230-939-3
- EC Name:
- Dimethyl(octyl)amine
- Cas Number:
- 7378-99-6
- Molecular formula:
- C10H23N
- IUPAC Name:
- dimethyl(octyl)amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sprague-Dawley
- Age at study initiation: young adult
- Housing: in stainless steel grid cages
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 (19-25)
- Humidity (%): 55 (40-70)
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 50 and 500 mg/kg at a constant volume-dosage of 10 ml/kg in maize oil
- No. of animals per sex per dose:
- two groups of five male and five female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 382 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 162 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 342 mg/kg bw
- Mortality:
- Four male and five female animals treated at 500 mg/kg died on the day of dosing. There was no death amongst the animals treated at 50mg/kg.
- Clinical signs:
- other: Ante mortem signs were restricted to prone posture in one female animal. The surviving animal treated at 500 mg/kg showed underactivity, staggering gait, hunched posture and piloerection; it was overtly normal after the first over night period. There was
- Gross pathology:
- Necropsy of the decedents revealed areas of fur staining and cases of distension of the small intestine by a yellow viscous fluid.
There was no macroscopic abnormality detected amongst the surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study the acute oral median lethal dosage (LD50) and slope of the dose response curve were:
Male: LD50=382 mg/kg
Female: LD50=162 mg/kg
Combined: LD50=342 mg/kg
The substance was assigned to the class "Toxic". - Executive summary:
The acute oral toxicity of the substance was investigated in two groups of five male and five female CD rats. The animals were starved overnight prior to dosing. The test material was administered at dosages of 50 and 500 mg/kg, at a constant volume-dosage of 10 ml/kg in maize oil.
Mortality and signs of reaction to treatment were recorded during a subsequent 14 -days observation period; the surviving were killed on the following day. All animals were subjected to necropsy.
Under the conditions of this study the acute oral median lethal dosage (LD50), of the test material was approximately 162 mg/kg in female animals. The substance was assigned to the class "Toxic".
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