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Diss Factsheets
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EC number: 213-928-8 | CAS number: 1067-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 111
- Deviations:
- yes
- Principles of method if other than guideline:
- only at garstic pH (1.2)
Test material
- Reference substance name:
- Dibutyltin di(acetate)
- EC Number:
- 213-928-8
- EC Name:
- Dibutyltin di(acetate)
- Cas Number:
- 1067-33-0
- Molecular formula:
- C12H24O4Sn
- IUPAC Name:
- dibutyltin di(acetate)
- Details on test material:
- - Name of test material : dibutyltin acetate Bu2Sn(OAc)2
- Radiochemical purity (if radiolabelling): >99 %
- Specific activity (if radiolabelling): 6.3 Ci/mmol
Unlabeled R2Sn (OAc)2, derivatives (prepared as needed by photodecomposition of R4Sn compounds on silica gel chromatoplates and TLC isolation); 1-14C-labeled preparations of Bu2Sn(OAc), with a specific activity of 6.3 mCi/mmol, and >99% radiochemical purity
- Name of test material : Bu2SnCl2 (unlabelled Bu2SnX2)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: n.a., in vitro
- Strain:
- not specified
Administration / exposure
- Route of administration:
- not specified
- Vehicle:
- water
Doses / concentrations
- Dose / conc.:
- 0.01 other: mol /L
- Control animals:
- no
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Hydrolysis Product: Dimeric Distannoxane, no Dibutyltin dichlorid detected
Metabolite characterisation studies
- Metabolites identified:
- yes
Applicant's summary and conclusion
- Conclusions:
- The dimeric distannoxane [(DBTC)2O]2 is the only in-vitro metabolite of DBTAc under the conditions of the study. Spectral data as well as melting point match very well with literature data (Davies 2004).
Dibutyltin dichloride (DBTC) – not even in traces - could not be detected in the reaction product.
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