Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 402-920-1 | CAS number: 103300-89-6 N-6-TRIFLUORACETYL-L-LYSYL-L-PROLIN; T.F.A. LYS PRO; TFA-LYS-PRO
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-05-25 to 1993-07-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Remarks:
- and photocell detection method
- Key result
- Atm. press.:
- 1 013 Pa
- Decomposition:
- yes
- Decomp. temp.:
- >= 370 K
- Sublimation:
- no
- Remarks on result:
- other: No melting until decomposition
- Conclusions:
- Summarizing the results stated above and the DSC analysis it can be reported, that the test substance ε-Trifluoroacetyl-L-lysyl-L-proline neither got an exact melting point nor a fixable melting range. The behavior of the test substance is better described as softening.
The DSC-analysis showed no endothermal proceedings, which must take place in the case of melting or boiling. But beginning at about 370 K a small exothermal proceeding was detected. This could signal a decomposition of the test substance.
Reference
RESULT OF THE PRELIMINARY TESTS:
The test substance ε-trifluoroacetyl-L-lysyl-L-proline showed no real melting point or melting range. The detection of the melting range with the Mettler thermosystem was caused only by the changing of optical properties of the test substance.
RESULTS OF THE DSC-ANALYSIS:
In the temperature range of 370 K up to 405 K a slight exothermal proceeding was detected. No endothermal reaction which could show a melting or boiling was seen.
RESULTS FROM THE METTLER THERMOSYSTEM:
The results of the three determinations were:
a) 362.7 K b) 362.9 K C) 359.2 K
But as described in the preliminary test this values only show the temperature at the point the light-transmission reached 20%.
RESULTS FROM THE BUCEI MELTING POINT APPARATUS:
Every change in optical properties of the test substance took place in a large temperature range. Therefore no exact melting point resulted.
In the following table the temperature ranges are shown in which the particular events took place.
356.1 K - 365.7 K: The optical properties of the test substance were varying. They were changing slowly from white, over milky to transparent. But no totally clear liquid was reached. In every case there were a few small bubbles inside the substance. Also in this temperature range a volumetric contraction was recognizable. But at the end of this range the substance wasn't a real liquid. It is better described as gel-like.
365.7 K - 370 K: In the lower area of the capillary tube a gaseous bubble was built. Above the bubble was the test substance. The substance became milky again.
370 K - 390 K: Anew the substance became transparent.
390 K - 406 K: The substance rose inside the capillary tube.
Description of key information
The substance decomposes at a temperature above 97 °C (> 307 K) before the melting point is reached.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.