Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-786-4 | CAS number: 869-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Remarks:
- Type of genotoxicity: other: mutations were not specified
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No experimental deails available. The negative result was provided as reference.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagen assay with Arabinopsis A report of the U.S. Envioronmental Protection Agency Gene-Tox Program
- Author:
- Rédei, GP
- Year:
- 1 982
- Bibliographic source:
- Mutation Research, 99 (1982) 243 - 255
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Experimental details were not provided.
- GLP compliance:
- no
- Type of assay:
- other: Arabinopsis thaliana
Test material
- Reference substance name:
- 2-chloroethyldiethylammonium chloride
- EC Number:
- 212-786-4
- EC Name:
- 2-chloroethyldiethylammonium chloride
- Cas Number:
- 869-24-9
- Molecular formula:
- C6H14ClN.ClH
- IUPAC Name:
- 2-chloroethyldiethylammonium chloride
- Details on test material:
- no information available.
Constituent 1
Test animals
- Species:
- other: Arabinopsis thaliana, a plant
- Details on test animals or test system and environmental conditions:
- Arabinopsis thaliana is a plant which was often used as biological model organism. No further data on the test plants and the experimental conditions were provided.
Administration / exposure
- Route of administration:
- other: not provided
- Details on exposure:
- no details were provided
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mM
Basis:
no data
Information given as "highest negative" concentration
Results and discussion
Any other information on results incl. tables
According to a cited reference (Müller, A.J. (1965) Arabinopsis Inf. Serv., 2, 22 - 24), the highest negative concentration of DEC is 500 mM. Further details were not provided.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative since no positive finding was reported
According to this Klimisch 4 information, the plant Arabinopsis thaliana showed no mutagenicity up to a concentration of 500 mM. further information was not provided. - Executive summary:
Rédei (1982) cited a publication from Müller (Müller, A.J. (1965) Arabinopsis Inf. Serv., 2, 22 - 24) in which the mutagenic potential of DEC on the plant Arabinopsis thaliana was evaluated. No experimental details were provided. It was stated that the highest concentration without mutagenic effects was 500 mM. Due to the very limited information on test material, experimental design, results and evaluation it is not possible to evaluate the relevance of this information. Therefore, this information was regarded as Klimisch 4 and will not be used for the risk assessment of DEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.