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Diss Factsheets
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EC number: 615-790-8 | CAS number: 72714-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
In vivo test system
Test animals
- Species:
- mouse
Study design: in vivo (LLNA)
- Vehicle:
- other: acetone
- Concentration:
- 3, 10 or 30% w/v
- Details on study design:
- The results are expressed as counts per minute (cpm) values per lymph node for each group. The activity of each test group is then divided by the activity of the vehicle control group to give the ratio for each concentration in comparison with the vehicle control. The criterion for a positive response is that at least one concentration of the test substance should elicit a 3-fold or greater increase in isotope incorporation relative to the vehicle control group, in which case the substance would be considered as a skin sensitiser.
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- other: Test:control group CPM/lymph node ratio
- Value:
- 2.03
- Test group / Remarks:
- 30% w/v
- Parameter:
- other: Test:control group CPM/lymph node ratio
- Value:
- 1.19
- Test group / Remarks:
- 10% w/v
- Parameter:
- other: Test:control group CPM/lymph node ratio
- Value:
- 0.98
- Test group / Remarks:
- 3% w/v
Any other information on results incl. tables
The counts per minute (CPM)/Lymph node value in the vehicle control group was 59. The corresponding CPM value for the test concentration of 3% w/v was 58, for the test concentration of 10% w/v it was 70 and for the test concentration of 30% w/v it was 120. The ratios of test group to control group were 0.98, 1.19 and 2.03.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is unlikely to be a moderate or strong skin sensitiser.
- Executive summary:
The skin sensitisation potential of the test substance was under GLP in a local lymph node assay conducted to principles similar to those of the OECD TG 429. The substance was dissolved in acetone and applied to the dorsum of the ear of mice, which is the common test species for the LLNA. Three test concentrations of 3%, 10% and 30% w/v in acetone were tested in addition to the vehicle control (acetone). The results were expressed as a counts per minute (cpm) value per lymph node for each group. The measured activity was then divided by the activity of the vehicle control group to give a test:control ratio for each concentration. The criterion for a positive response is that one or more concentrations of the test substance should elicit a 3-fold or greater increase in isotope incorporation relative to the vehicle control group. Since the test:control ratio was less than 3 in all three test groups, the substance was considered unlikely to be a moderate or strong skin sensitiser.
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