Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 01-1957 to 03-1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non standard test method used. Limited information on the test substance, animals tested/environmental conditions. Incomplete examinations performed and only 4 animals used per dose level. Necropsies were not performed on all animals. Non GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: recommendations outlined by the National Safety Council.
- Principles of method if other than guideline:
- One-Day Cuff Method used by Draize and associates as modified by Smyth and associates.
- GLP compliance:
- no
- Test type:
- other: one-day cuff method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(octylthio)ethanol
- EC Number:
- 222-598-4
- EC Name:
- 2-(octylthio)ethanol
- Cas Number:
- 3547-33-9
- Molecular formula:
- C10H22OS
- IUPAC Name:
- 2-(octylsulfanyl)ethan-1-ol
- Reference substance name:
- Ethanol, 2-(octylthio)-
- IUPAC Name:
- Ethanol, 2-(octylthio)-
- Reference substance name:
- 2-hydroxyethyl-n-octyl sulfide
- IUPAC Name:
- 2-hydroxyethyl-n-octyl sulfide
- Details on test material:
- - Name of test material (as cited in study report): 2-hydroxyethyl-n-octyl sulfide
- Physical state: colorless liquid
- Stability under test conditions: Stable under all usual conditions of storage and use. Avoid highly alkaline emulsifiers in emulsion concentrations.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: ~ 2.0 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Entire trunk
- % coverage: 1/10 of the body surface
- Type of wrap if used: impervious plastic film
TEST MATERIAL
- Constant volume or concentration used: no
- Other: The calculated dose of the undiluted test substance was introduced through a catheter. - Duration of exposure:
- 24 hours
- Doses:
- 7.95 ml/kg, 15.80 ml/kg and 32 ml/kg (estimated to be 7,433, 14,773 and 29,920 mg/kg, respectively based on a density of 0.935 g/cm3 at 15.6 °C)
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes; all fatalities were autopsied to exclude extraneous causes of death. Some survivors were autopsied for gross lesions.
- Other examinations performed: Mortality was monitored for 14 days. After the 24 hour exposure the skin was examined for gross changes.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 15 mL/kg bw
- Mortality:
- 7.95 ml/kg (7,433 mg/Kg) group-1 rabbit died 2 days after dosing.
15.80 ml/kg (14,773 mg/kg) group-1 rabbit died 2 days after dosing and another rabbit died 7 days after dosing. - Clinical signs:
- other: The skin of all animals showed slight erythema and slight subcutaneous edema when removed from the dam. Two of the four rabbits in the mid dose group were in a weakened condition. Although the health of the other two rabbits on this dose level seemed sat
- Gross pathology:
- Autoposies of the fatalities and survivors revealed no significatn findings.
Any other information on results incl. tables
The dose of 32 mL/kg resulted in the volume of fluid exceeding the capacity of the wrap on the dams; therefore, the dosing was discontinued.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The LD50 of the test substance by dermal application, approximated from the available data, was estimated to be 15 ml/kg ( 14,025 mg/Kg).
- Executive summary:
In an acute dermal toxicity study that followed the recommendations outlined by the National Safety Council, groups of 4 male albino rabbits weighing about 2.0 kg were placed in two dose groups (7.95 and 15.80 mL/kg, or 7433 and 14773 mg/kg/day, respectively) of ethanol, 2-(octylthio). The fur was closely clipped over the entire trunk (about 1/10 of the body surface) and the dose was retained beneath an impervious plastic film. The calculated dose of the undiluted test substance was introduced through a catheter after the dam was in place. The rabbits were then confined in stocks. The dam was removed after 24 hours’ contact, and the skin was examined for gross changes. Mortality was considered complete after 14 days. All fatalities were autopsied to exclude extraneous causes of death. Some survivors were autopsied for gross lesions. The skin of all animals showed slight erythema and slight subcutaneous edema when removed from the dam. Two of the 4 rabbits in the high dose group were in a weakened condition; 1 died on the second day, and the other survived but failed to gain weight. Although the health of the other 2 rabbits in this group seemed satisfactory, when the dams were removed, their condition subsequently deteriorated. One died on the seventh day; the other survived but lost weight. Autopsies of the fatalities and survivors revealed no significant findings. Although an exact determination of the LD50 could not be made, and approximation from the available data suggested it to be 15 mL/kg or 14,025 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.