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EC number: 248-670-5 | CAS number: 27816-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
In general, 2-cyanoacrylates react rapidly in contact with water to form polymers in exogenous reactions. Therefore, is technically not possible to assess the skin sensitizing potential of the isolated 2-methoxyethyl 2-cyanoacrylate monomer as it can be expected that during the test procedure polymerisation is triggered by humidity of the ambient air or the superficial skin layers, respectively. This reaction is faster than the penetration of monomers through skin, making it unlikely to expose cells involved in a sensitization reaction to the monomeric substance.
However, allergic reactions towards cyanoacrylate adhesives are occasionally described in the literature. These case reports often lack a clear description which substance caused the observed reactions. Both the monomers and degradation products of the polymer, including formaldehyde, are discussed to be causative to the reactions. As the full composition of the commercial products have not been described in most of the case reports, it could not be clarified which chemical substances were present and contributed to the adverse skin effects. Considering the widespread industrial and domestic use of cyanoacrylates, these case reports are rather seldom and do not reflect the general sensitizing properties of cyanoacrylates.
In order to evaluate the potential relevance of monomeric residues and impurities in a cyanoacrylate polymer as well as of degradation products or additives which are added to the product formulation, a study was performed with 1-methylheptyl 2-cyanoacrylate. Water-based and lipid-based extracts of the polymerized adhesive formed from 1-methylheptyl 2-cyanoacrylate have been made (in physiological saline and cotton seed oil) according to standard procedures for medicinal products, and were investigated in the Magnussen-Kligman Maximization test. No potential for skin sensitization was observed in this test compared with the control. A similar study with the same result was also performed with n-butyl 2-cyanoacrylat confirming the low extractability of any skin sensitizing side component or residue from the polymer. Such results can be assumed for other cyanoacrylates like 2 -methoxyethyl 2 -cyanoacrylate as well.
Study is technically not feasible as 2-methoxyethyl 2-cyanoacrylate polymerizes on contact with moisture.Thus, in accordance with annex XI section 2 of Regulation (EC) No 1907/2006 testing of 2-methoxyethyl 2-cyanoacrylate on skin senistization is waived.
Justification for classification or non-classification
2 -Methoxyethyl 2-cyanoacrylate binds instantaneously to the skin's surface and polymerizes. The polymerized material is not able to penetrate into the epidermis. Hence, the substance is not considered to be a skin sensitizer and does not require classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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