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Diss Factsheets
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EC number: 203-518-7 | CAS number: 107-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity:
- oral: LD50 > 6400 mg/kg bw (BASF 1972, XXI/221)
- dermal: > 2000 mg/kg bw (Moreno 1973)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Study was performed acc. internal BASF method, which was in part equivalent to OECD Guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: mean: 268 g (male), 183 g (female) - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2%, 20%, 30%
- Other: vehicle solution contained 2-3 drops of cremophor EL (as solubilizer) - Doses:
- 200, 1600, 3200, 6400 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of weighing: prior to begin and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Determination of the LD50 calculated according to Finney
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Mortality:
- 200 mg/kg bw: 0/20 deaths
1600 mg/kg bw: 0/20 deaths
3200 mg/kg bw: 1/20 deaths; 1 male died within 48 h
6400 mg/kg bw: 0/20 deaths - Clinical signs:
- other: Delayed and intermittent respiration, Dyspnea and atony
- Gross pathology:
- Enlarged stomach
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 800 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- No reliable study performed according to regulatory guidelines was available and thus, a study for the third route of exposure was waived.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable data, report with limited documentation
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An acute dermal toxicity study on rabbits was performed
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 animals used
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality observed
- Clinical signs:
- other: Symptomatology: none
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
In the chosen key study for acute oral toxicity in part equivalent to OECD guideline 401, ten Sprague-Dawley rats per sex and dose were treated via gavage by doses of 200, 1600, 3200, 6400 mg/kg bw hydroxycitronellal in carboxymethyl cellulose (BASF 1972, XXI/221). One single male animal in the 3200 mg/kg dose group died, and a LD50 value of >6400 mg/kg bw was set.
In a supportive study, the LD50 was found to be >5000 mg/kg/bw when 10 rats received application of 5000 mg/kg bw (Moreno, 1973).
Acute inhalative toxicity
No valid key study is available for hydroxycitronellal. However, for the coverage of a second and human relevant route of exposure, a study on acute dermal toxicity is available. No evident acute toxicity after single oral or dermal exposure has been observed for hydroxycitronellal. In support, in an inhalation hazard test in rats (exposure to a vapour saturated atmosphere at 20°C and 40°C for 8 hours) no mortality was observed, providing further evidence for the absence of an acute inhalative toxicity potential (BASF 1972, XX/221a). Overall, no further testing in animals is considered mandatory.
Acute dermal toxicity
In the chosen key study for acute dermal toxicity in two rabbits, a LD50 of >2000 mg/kg bw has been reported (Moreno, 1973).
Justification for classification or non-classification
The present data on acute oral and dermal toxicity do not fulfill the criteria laid down in regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
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