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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 10th December to 15th December 1984
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted in 1984 and is not described as having been conducted to any recognised guideline. The method is explained in very brief detail within the report and lacks important information such as the demographics and the medical history of the volunteers which is critical to the validity of the results. Neither the batch details nor the purity of the substance are reported and the test is described as being conducted using a preparation of the substance (present at only 5%) in Vaseline. Concurrent vehicle controls were run during the study. The results are presented in table form with simple “positive/negative” descriptions of any reaction without being qualified. As the substance was not tested up to a concentration approaching full strength, it cannot be considered as reliable for assessing the irritancy potential of the substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A human patch test was performed to assess the irritation potential of the test material. An application of the test material at 5 % in vaseline was applied to the upper arm of human volunteers.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- EC Number:
- 289-296-2
- EC Name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- Cas Number:
- 87061-04-9
- Molecular formula:
- C13H26O3
- IUPAC Name:
- 3-{[5-methyl-2-(propan-2-yl)cyclohexyl]oxy}propane-1,2-diol
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 25
- Sex: 16 males and 9 females
- Age: Aged between 22 and 61 - Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- A 5 % sample of the test material was prepared in Vaseline on a Toril test plaster. The test plasters were applied to the upper arms of the volunteers as an occluded patch for 48 hours. A control consisting of Vaseline alone was used.
- Examinations:
- - Irritation: Readings were performed at one hour and twenty four hours after removal of the patch.
Results and discussion
- Results of examinations:
- - Irritation: No positive reactions were observed.
Any other information on results incl. tables
Table 1: Results
Volunteer Number |
Sex |
Age |
Vaseline Control |
5 % Test Material |
|
24 Hours |
48 Hours |
||||
1 |
M |
33 |
- |
- |
- |
2 |
M |
34 |
- |
- |
- |
3 |
F |
25 |
- |
- |
- |
4 |
F |
22 |
- |
- |
- |
5 |
M |
38 |
- |
- |
- |
6 |
M |
37 |
- |
- |
- |
7 |
M |
22 |
- |
- |
- |
8 |
M |
36 |
- |
- |
- |
9 |
M |
37 |
- |
- |
- |
10 |
M |
32 |
- |
- |
- |
11 |
F |
22 |
- |
- |
- |
12 |
M |
42 |
- |
- |
- |
13 |
M |
27 |
- |
- |
- |
14 |
M |
24 |
- |
- |
- |
15 |
M |
23 |
- |
- |
- |
16 |
M |
26 |
- |
- |
- |
17 |
M |
38 |
- |
- |
- |
18 |
M |
35 |
|||
19 |
F |
22 |
- |
- |
- |
20 |
F |
28 |
- |
- |
- |
21 |
F |
40 |
- |
- |
- |
22 |
F |
19 |
- |
- |
- |
23 |
M |
47 |
- |
- |
- |
24 |
F |
61 |
- |
- |
- |
25 |
F |
23 |
- |
- |
- |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, no irritation was observed in human volunteers.
- Executive summary:
A human patch test was performed on 25 volunteers using a 5 % preparation (in Vaseline) of the test material. The subjects were exposed to the test material for 48 hours using an occluded patch. None of the volunteers of the study exhibited a positive reaction to the test material.
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