Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-764-3 | CAS number: 373-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF-Test
- Principles of method if other than guideline:
- 50 mm3 of the test substance were introduced into the lower conjunctival sac of 2 rabbits' right eyes. The left eyes were used as control and treated with talcum powder. The eyes were not washed after the application. The animals were observed for 8 days with readings after 1 hour, 24 hours and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Octamethylenediamine
- EC Number:
- 206-764-3
- EC Name:
- Octamethylenediamine
- Cas Number:
- 373-44-4
- Molecular formula:
- C8H20N2
- IUPAC Name:
- octane-1,8-diamine
- Details on test material:
- - Name of test material (as cited in study report): Oktamethylendiamin
- Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- unchanged
- Duration of treatment / exposure:
- 8 days
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- >= 3
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosion after an exposure of 1 hour, not reversible within 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- >= 3
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosion after an exposure of 24 hours, not reversible within 8 days
Any other information on results incl. tables
50 mm3 of the test substance were introduced into the lower conjunctival sac of 2 rabbits' right eyes. The left eyes were used as control and treated with talcum powder. The eyes were not washed after the application. The animals were observed for 8 days with readings after 1 hour, 24 hours and 8 days while the effects were graded as follows:
Grading according to BASF-Test for necrosis (N), redness (R) and opacity (Tr) |
Description |
Grading according to OECD 405 |
Ø |
no symptom |
0 |
(+) |
questionable |
0 |
+ |
slight |
1 |
++ |
marked |
2 |
+++ |
severe |
≥3 |
Iritis + or ++ = Iritis grade 1 or 2
The following symptoms were reported:
Time of exposure |
Symptoms of treated eyes |
Symptoms of control eyes |
1 hour |
corrosion |
R+ |
24 hours |
corrosion |
Ø |
8 days |
corrosion, crusts |
Ø |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information corrosive
- Conclusions:
- Classification: irreversible effects on the eyes
- Executive summary:
50 mm3 of the test substance were introduced into the lower conjunctival sac of 2 rabbits' right eyes. The left eyes were used as control and treated with talcum powder. The eyes were not washed after the application. The animals were observed for 8 days with readings after 1 hour, 24 hours and 8 days. After an exposure of 1 hour the eyes treated with the test substance showed eye corrosion which was not reversible within 8 days. The control eyes showed slight redness after 1 hour of treatment which was fully reversible within 24 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.