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Diss Factsheets
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EC number: 203-139-7 | CAS number: 103-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization for test chemical was estimated to be not sensitizing on guinea pig and humans. Thus it can be concluded that the substance, the test chemical has no skin sensitization effects.
Hence, test chemical can be considered to be not sensitizing to skin.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling Database
- Principles of method if other than guideline:
- To estimate the allergenic potential of the test chemical in guinea pigs and humans
- GLP compliance:
- not specified
- Type of study:
- other: estimated data
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid - Species:
- other: human
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: no data
- Vehicle:
- no data
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- other: no data
- Vehicle:
- no data
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- no data available
- Details on study design:
- no data available
- Challenge controls:
- no data available
- Positive control substance(s):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- No signs of sensitization observed
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization for test chemical was estimated to be not sensitizing on guinea pig and humans. Thus it can be concluded that the substance, the test chemical has no skin sensitization effects.
Hence, test chemical can be considered to be not sensitizing to skin. - Executive summary:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization for test chemical was estimated to be not sensitizing on guinea pig and humans. Thus it can be concluded that the substance, the test chemical has no skin sensitization effects.
Hence, test chemical can be considered to be not sensitizing to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitization
The dermal sensitization potential of the test chemical was assessed based on the available results from the various test chemicals.
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization for test chemical was estimated to be not sensitizing on guinea pig and humans. Thus it can be concluded that the substance, the test chemical has no skin sensitization effects.
Hence, test chemical can be considered to be not sensitizing to skin.
This is supported by the results of a human maximization test conducted to assess the potential of contact allergy caused by the chemical under occlusive condition. The test material was mixed into petrolatum N.F. at 4% concentration and applied to the same forearm sites under occlusion for five alternate-day 48-hour periods. Each application of the test material was preceded by treatment of the patch site with 5% aqueous sodium lauryl sulfate under occlusion.
Following a ten day rest period challenge patches of the test material were applied to fresh sites on the scapular backs under occlusion for 48 hours. The challenge sites were pretreated for one hour with 10% aqueous sodium lauryl sulfate. Clinical evaluations were made at 48 and 72 hours.
The test chemical failed to induce any signs of dermal sensitization after 72 hours of observation. Hence, the test chemical can be considered to be not sensitizing to skin.
The above results are further supported by a study performed on the ingredients of an aqueous cream formulation to detect potential sensitizers present. The test chemical is added to 1% aqueous cream and hydrous ointment as a preservative. A standard patch testing series was performed with the ingredients of aqueous cream in 2736 patients to identify potential skin sensitizers present in the formulation.
1% test chemical in petrolatum failed to induce any signs of irritation or sensitization at 2 or 4 days after application.
Hence the test chemical can be considered to be not sensitizing to human skin.
By applying the weight of evidence approach, the test chemical can be considered to be not sensitizing to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
By applying the weight of evidence approach, the test chemical can be considered to be not sensitizing to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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