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Diss Factsheets
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EC number: 201-911-8 | CAS number: 89-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
A guideline-conform ready biodegradability study was being conducted. Menthyl acetate was not readily biodegradable in the study. A fraction of 48% was biodegraded at the end of the 28-day study period (clear indication that extensive primary biodegradation occurred) and biodegradation was still ongoing. Taking into account additional modelling with the BIOWIN program the substance can be considered as inherently biodegradable.
As menthyl acetate hydrolyses quite fast under environmental conditions (pH7) with a half-life of only 6 days, the substance can be regarded as rapidly degradable under environmental conditions. With a half-life time of < 16 days the criteria for rapid degradation according to the CLP/GHS criteria are as well fulfilled as the degradation products D,L-Menthol (CAS 89 -78 -1) and acetic acid (CAS 64-19-7) are not classified as hazardous to the aquatic environment. Furthermore, referring to ECHA PBT guidance document a "substance fulfils the P(vP) criterion if T1/2 > 40 (60) days". As it further can be shown that the two hydrolysis transformation products D,L-Menthol and acetic acid are not PBT/vPvB, according to ECHA PBT guidance document no further testing of degradation is required for the PBT/vPvB assessment. A persistence of menthyl acetate in the environment is therefore not expected.
The log Koc value was predicted with the program KOCWIN and with three QSPR methods. The log Koc = 3.196 indicates that the substance has low mobility in soil and sediment according to the classification scheme of McCall et al. (1981).
The Henry's Law constant that can be calculated from the available information on vapour pressure and water solubility shows that the substance is volatile from water surfaces under environmental conditions.
The BCF of the substance was calculated with the program BCFBAF using a fragment-based approach (Meylan et al. 1999) and with a QSAR built on the relationship between log Kow and BCF (Veith et al. 1979). The predicted values were 202 L/kg and 501 L/kg, respectively. The B criterion is not fulfilled for the substance menthyl acetate and the substance is considered as not bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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