Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientific acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- 3,4-dichlorophenyl isocyanate was diluted with Lutrol and administered, by intubation, to rats. The animals were given a volume equivalent to 0.5% of their body weight. Four groups of 5 males were given dose levels of 201, 342, 582 and 990 mg/kg and four groups of 5 females were given 41, 70, 118 and 201 mg/kg
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- male: 201, 342, 582 and 990 mg/kg bw
female: 41, 79, 118 and 201 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 402 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 91 mg/kg bw
- Mortality:
- male:
201 mg/kg: 0/5/5 (deaths/symptoms/no. exposed)
342 mg/kg: 2/5/5
582 mg/kg: 4/5/5
990 mg/kg: 5/5/5
female:
41 mg/kg: 1/5/5 (deaths/symptoms/no. exposed)
70 mg/kg: 0/5/5
118 mg/kg: 5/5/5
201 mg/kg: 4/5/5 - Clinical signs:
- other: lethargy, pilo erection, convulsions at high dose levels - all death occured within 24 hours post-treatment
- Gross pathology:
- gastrointestinal inflammation
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Executive summary:
method: 3,4 -Dichlorophenyl isocyanate was diluted with Lutrol and administered, by intubation, to rats. The animals were given a volume equivalent to 0.5% of their body weight. Four groups of 5 males were given dose levels of 201, 342, 582 and 990 mg/kg and four groups of 5 females were given 41, 70, 118 and 201 mg/kg.
result: LD50(male) = 402 mg/kg bw; LD50(female) = 91 mg/kg bw
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