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EC number: 249-047-0 | CAS number: 28473-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study on a read-across compound, only briefly described in the secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 983
- Reference Type:
- review article or handbook
- Title:
- Toxicity profile. Di(2-ethylhexyl) sebacate
- Author:
- Bibra
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 12 rats were exposed to DEHS at 25 or 250 mg/m3, 4 hrs/day, 5 days/wk for 13 wk.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- di-(2-ethylhexyl) sebacate
- IUPAC Name:
- di-(2-ethylhexyl) sebacate
- Reference substance name:
- Bis(2-ethylhexyl) sebacate
- EC Number:
- 204-558-8
- EC Name:
- Bis(2-ethylhexyl) sebacate
- Cas Number:
- 122-62-3
- IUPAC Name:
- bis(2-ethylhexyl) sebacate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): di(2-ethylhexyl) sebacate
- Molecular formula (if other than submission substance): C26-H50-O4
- Molecular weight (if other than submission substance): 426.677
- Smiles notation (if other than submission substance): C([C@@H](CCCC)CC)OC(CCCCCCCCC(OC[C@@H](CCCC)CC)=O)=O
- InChl (if other than submission substance): InChI=1S/C26H50O4/c1-5-9-17-23(7-3)21-29-25(27)19-15-13-11-12-14-16-20-26(28)30-22-24(8-4)18-10-6-2/h23-24H,5-22H2,1-4H3
- Structural formula attached as image file (if other than submission substance): see Fig. 1
- Substance type: no data in citing source
- Physical state: no data in citing source
- Analytical purity: no data in citing source
- Impurities (identity and concentrations): no data in citing source
- Composition of test material, percentage of components: no data in citing source
- Isomers composition: no data in citing source
- Purity test date: no data in citing source
- Lot/batch No.: no data in citing source
- Expiration date of the lot/batch: no data in citing source
- Stability under test conditions: no data in citing source
- Storage condition of test material: no data in citing source
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data in citing source
- Age at study initiation: no data in citing source
- Weight at study initiation: no data in citing source
- Fasting period before study: no data in citing source
- Housing: no data in citing source
- Diet (e.g. ad libitum): no data in citing source
- Water (e.g. ad libitum): no data in citing source
- Acclimation period: no data in citing source
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data in citing source
- Humidity (%): no data in citing source
- Air changes (per hr): no data in citing source
- Photoperiod (hrs dark / hrs light): no data in citing source
IN-LIFE DATES: no data in citing source
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data in citing source
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data in citing source
- Method of holding animals in test chamber: no data in citing source
- Source and rate of air: no data in citing source
- Method of conditioning air: no data in citing source
- System of generating particulates/aerosols: no data in citing source
- Temperature, humidity, pressure in air chamber: no data in citing source
- Air flow rate: no data in citing source
- Air change rate: no data in citing source
- Method of particle size determination: no data in citing source
- Treatment of exhaust air: no data in citing source
TEST ATMOSPHERE
- Brief description of analytical method used: no data in citing source
- Samples taken from breathing zone: no data in citing source - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data in citing source.
- Duration of treatment / exposure:
- 13 wk
- Frequency of treatment:
- 4 hr/day, 5 days/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25 or 250 mg/m3
Basis:
no data
- No. of animals per sex per dose:
- Total of 12 animals of unspecified sex in each of the two groups.
- Control animals:
- not specified
- Details on study design:
- - Dose selection rationale: no data in citing source
- Rationale for animal assignment (if not random): no data in citing source
- Rationale for selecting satellite groups: from citing sources, satellite groups don't appear to have been selected
- Post-exposure recovery period in satellite groups: from citing sources, satellite groups don't appear to have been selected
- Section schedule rationale (if not random): no data in citing source - Positive control:
- No data in citing source.
Examinations
- Observations and examinations performed and frequency:
- Rats were apparently assessed 1, 7 and 13 weeks after exposure, but no further details are given on any of the examinations performed.
- Sacrifice and pathology:
- GROSS PATHOLOGY: no data in citing source
HISTOPATHOLOGY: no data in citing source - Other examinations:
- No data in citing source.
- Statistics:
- No data in citing source.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- A secondary source, compiled prior to the results of this study being subject to final analysis, stated that "no significant effects appear evident". Presumably there were no severe treatment-related clinical signs of toxicity, and no treatment-related mortality, but no specific details are given. The finalised results of this study may not have been formalised.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 250 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Apparently no observed adverse effects at highest tested concentration
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a study very briefly described in the secondary literature, no adverse effects were evidently observed in rats following inhalation exposure to DEHS for 13 weeks, resulting in a study NOAEC of 250 mg/m3.
- Executive summary:
A subchronic inhalation study has been conducted on DEHS, a structurally-related read-across compound for DIDS, and is reported very briefly in the secondary literature.
Groups of 12 rats were treated with DEHS at either 25 or 250 mg/m3 for 4 hours/day, 5 days/week, for 13 weeks. Rats were apparently "assessed" after 1, 7 and 13 weeks of exposure [no details are given on the extent of examination, and presumably more frequent assessments were also performed e.g. for mortality and clinical signs of toxicity].
According to a secondary source, final analysis of the data has not been formalised. However, no significant adverse effects were evidently reported [no further details given], therefore a study NOAEC of 250 mg/m3 can be assumed.
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