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EC number: 287-820-4 | CAS number: 85586-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 15 January to 26 February 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted in accordance with draft international guidelines in a GLP testing laboratory. Study, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
- Qualifier:
- according to guideline
- Guideline:
- ISO Draft (BOD Test for Insoluble Substances)
- Version / remarks:
- ISO/TC 147/SC 5/WG 4N 141
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- GLP Statement
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n/a - Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water
- Details on inoculum:
- Natural seawater continuously pumped to testing laboratory from pier in Scapa Flow, Flotta, Orkney (5 January 2007), depth of collection 2 metres below MLWS, Salinity at collection 34-37 parts per thousand. Temperature range 6-14 deg C. 5-7 days before test, seawater passed by gravity through a 45µm filter into an aging tank. Seawater was aged for 10 days at a temperature of 18.9-19.7 deg C.
- Duration of test (contact time):
- 42 d
- Initial conc.:
- 11.11 mg/L
- Based on:
- test mat.
- Initial conc.:
- 5.56 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- The study was undertaken with the Test material, test material + soluble reference (Sodium benzoate), and control/blank/reference.
Three replicates were prepared and tested for each test condition. - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- n/a
- Test performance:
- The test was performed at two different addition concentrations:
PR-4758(a) = 11.11 mg/L
PR-4758(b) = 5.56 mg/L - Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 63
- Sampling time:
- 28 d
- Remarks on result:
- other: PR-4758(a) Addition rate 11.11 mg/L
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 69
- Sampling time:
- 42 d
- Remarks on result:
- other: PR-4758(a) Addition rate 11.11 mg/L
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 80
- Sampling time:
- 28 d
- Remarks on result:
- other: PR-4758(b) Addition rate 5.56 mg/L
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 85
- Sampling time:
- 42 d
- Remarks on result:
- other: PR-4758(b) Addition rate 5.56 mg/L
- Parameter:
- COD
- Value:
- 1.8 g O2/g test mat.
- Results with reference substance:
- The results with the reference substance were valid, reaching 99 % biodegradation within 14 days, indicating that the sea water used in the test contained a satisfactory population of viable bacteria.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- The ISO Marine BODIS study indicated that the test substance (PR-4758) did degrade in seawater (63% in 28 days at an addition concentration of 11.11mg/L) and exhibited an inhibition of 23% to seawater bacteria.
- Executive summary:
Biodegradation testing was performed on the test substance PR-4758 based on the ISO TC/147, SC5/WG4 Marine BODIS study.
The test substance was degraded by 63 % after 28 days and 69 % after 42 days based on COD calculations and measurements to account for oxygen consumption.
Therefore, test substance PR-4758 was shown to biodegrade in seawater.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 11 Sept to 9 Oct 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted in accordance with international guidelines in a GLP testing laboratory
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 306 - Biodegradability in Seawater
- Deviations:
- no
- Principles of method if other than guideline:
- n/a
- GLP compliance:
- yes
- Remarks:
- GLP Statement
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n/a - Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water
- Details on inoculum:
- Natural seawater sample taken from NIVA's research station at Solbergstrand (5 September 1995), depth of collection 40 metres, Salinity at collection 34 parts per thousand. Seawater was aged by storing at the test temperature and by gentle aeration, with coarse particles removed by sedimentation and decanting prior to use.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 3 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- Test conditions:
- Temperature 20.0 +/- 2.4 deg C
- closed bottle in the dark
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 2.5 mg/L
- Preliminary study:
- n/a
- Test performance:
- Being a UVCB it was not possible to quantify and determine all components fo the test substance and thus the Chemical Oxygen Demand (COD) value was used instead of the Theoretical Oxygen Demand (ThOD).
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 26
- Sampling time:
- 5 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 36
- Sampling time:
- 15 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 48
- Sampling time:
- 28 d
- Remarks on result:
- other: Oxygen consumption due to nitrification taken into consideration
- Details on results:
- See Table below
- Results with reference substance:
- See Table below
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: further study is required
- Conclusions:
- The OECD 306 Guideline is not a ready biodegradability test; a positive result (>70% DOC removal; >60% ThOD) demonstrates a potential for biodegradation in the marine environment, but a negative result only indicates that further study is necessary.
The result of this study was negative, and therefore indicates that further investigation is required. - Executive summary:
A study was completed to examine the potential for biodegradation of PR-4758 (also known as F-9069) in seawater.
The study met the validation criteria, with the reference substance (inoculum control) achieving 50% degradation within 5 days (actual value = 69%), and the blank respiration did not exceed 30% of the oxygen in the test bottle.
PR-4758 gave a negative result (48% after 28 days) in this study. Whilst this result does not indicate that the test substance does not have the potential to degrade in the marine environment it does indicate that further investigation is necessary.
Referenceopen allclose all
Summary of Results Table
Test Material | PR-4758(a) | PR-4758(b) |
Solubility in Water | Soluble | Soluble |
COD (mg O2/mg) | 1.8 | 1.8 |
Addition rate (mg/L) | 11.11 | 5.56 |
% inhibition (day 28) | 23% | 24% |
28 day biodegradation | 63% | 80% |
Final 42 day biodegradation | 69% | 85% |
% inhibition (day 42) | 20% | 18% |
Average dissolved oxygen concentration (mg O2/L) corrected for barometric pressure
|
Day |
||||||
0 |
7 |
14 |
21 |
28 |
35 |
42 |
|
Oxygen consumption blank |
6.92 |
6.74 |
6.93 |
7.15 |
7.09 |
6.76 |
6.84 |
Sodium benzoate |
6.97 |
3.70 |
4.72 |
6.63 |
6.73 |
6.69 |
6.89 |
PR-4758(a) |
6.89 |
5.46 |
6.00 |
6.75 |
6.44 |
6.48 |
6.77 |
PR-4758(a) + Sodium benzoate |
6.95 |
2.93 |
5.45 |
6.23 |
6.18 |
6.24 |
6.74 |
Percentage Degradation of PR-4758(a)
|
100% |
Sum of BOD (mg O2 per bottle) |
|||||
7 |
14 |
21 |
28 |
35 |
42 |
||
PR-4758(a) |
20 |
4.90 |
8.51 |
10.04 |
12.55 |
13.62 |
13.89 |
PR-4758(a) + Sodium benzoate |
40 |
14.67 |
20.38 |
23.88 |
27.38 |
29.39 |
29.78 |
|
100% |
Percentage biodegradation |
|||||
7 |
14 |
21 |
28 |
35 |
42 |
||
PR-4758(a) |
20 |
25 |
43 |
50 |
63 |
68 |
69 |
PR-4758(a) + Sodium benzoate |
40 |
37 |
51 |
60 |
69 |
74 |
75 |
Average dissolved oxygen concentration (mg O2/L) corrected for barometric pressure
|
Day |
||||||
0 |
7 |
14 |
21 |
28 |
35 |
42 |
|
Oxygen consumption blank |
6.92 |
6.74 |
6.93 |
7.15 |
7.09 |
6.76 |
6.84 |
Sodium benzoate |
6.97 |
3.70 |
4.72 |
6.63 |
6.73 |
6.69 |
6.89 |
PR-4758(b) |
6.97 |
5.93 |
6.50 |
6.67 |
6.72 |
6.60 |
6.89 |
PR-4758(b) + Sodium benzoate |
6.97 |
2.87 |
6.05 |
6.54 |
6.30 |
6.32 |
6.72 |
Percentage Degradation of PR-4758(b)
|
100% |
Sum of BOD (mg O2 per bottle) |
|||||
7 |
14 |
21 |
28 |
35 |
42 |
||
PR-4758(b) |
10 |
3.11 |
4.78 |
6.60 |
8.02 |
8.66 |
8.48 |
PR-4758(b) + Sodium benzoate |
30 |
14.88 |
18.28 |
20.61 |
23.68 |
25.36 |
25.84 |
|
100% |
Percentage biodegradation |
|||||
7 |
14 |
21 |
28 |
35 |
42 |
||
PR-4758(b) |
10 |
31 |
48 |
66 |
80 |
86 |
85 |
PR-4758(b) + Sodium benzoate |
30 |
50 |
61 |
69 |
79 |
85 |
86 |
Summary Table of Result
Time (days) |
% Biodegradation | ||
Inoculum Control | Test Substance | Control for inhibitory action | |
5 | 69 | 26 | 44 |
15 | 69 | 36 | 51 |
28 | 68 | 48 | 56 |
Description of key information
Not readily biodegradable; OECD 306; Bjorg S. Nesgard (1995)
Readily biodegradable; ISO BODIS; Hudson B. (2007)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Two studies exist for the biodegradation of PR-4758 in marine water, these are to be used in combination in a weight-of-evidence. The studies were conducted to GLP standards in a GLP certified laboratory. The study was in accordance with OECD guideline 306 (1992). Both studies met the qualifying criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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