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Diss Factsheets
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EC number: 285-503-5 | CAS number: 85114-00-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
TOXICOKINETIC BEHAVIOUR
Physico-chemical properties:
2-ethylhexanoic acid, monoester with propane-1,2-diol (FX511) is a clear colourless liquid at room temperature and pressure and the molecular weight is 202.3 g/mol. The mean measured Log P (octanol-water) is 2.98 at 40 degC and the water solubility has been determined as 1.79 g/L at 20 degC. The vapour pressure value is 1.2 Pa at 25 degC which is indicative that the substance is not volatile at room temperature and pressure, therefore inhalation exposures are not a concern.
Absorption:
There are no directly measured ADME data by any route for FX511.
Oral: In the key study for acute oral toxicity (Snell, 1995), some minor clinical signs were present during the first day after a single 2000 mg/kg bw dose was administered unchanged and by oral gavage, suggesting the material had absorbed rapidly into the body. The animals appeared normal after 1 day, which may be indicative that the absorbed material is rapidly metabolised, cleared and excreted. There are no repeat dose studies for this material.
Inhalation: no data, as the substance is not volatile and not expected to be inhaled.
Dermal: FX511 is not a skin irritant. It is not a skin sensitiser.
In the key study for acute dermal toxicity (Sanders, 2012), there are no reported systemic effects and no mortality when the substance was dosed neat up to 2000 mg/kg. It is not possible from the data to ascertain whether or not the substance absorbed across the skin and into systemic circulation.
Distribution:
There are no specific data on differential distribution to organs.
Metabolism:
There is no information on metabolism of this substance in the body.
FX511 is likely to undergo some degree of hydrolysis by esterases, particularly under acidic conditions to form 2-ethylhexanoic acid and propan-1,2-diol.
There is no evidence from in vitro genotoxicity studies to suggest that metabolism plays a role in the genotoxic properties of this substance. FX511 is non genotoxic in the absence and presence of metabolic activation.
Excretion:
No data are available to determine the pathways or extent of excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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