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Diss Factsheets
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EC number: 216-957-4 | CAS number: 1708-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Two Vienna White rabbits were treated for 3 minutes, 1 hour, and 4 hours, respectively, with the test substance under occlussive conditions. After the application time, the skin was washed with Lutrol or Lutrol/water (1:1) and animals were observed for 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,5-dihydrofuran
- EC Number:
- 216-957-4
- EC Name:
- 2,5-dihydrofuran
- Cas Number:
- 1708-29-8
- Molecular formula:
- C4H6O
- IUPAC Name:
- 2,5-dihydrofuran
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dihydrofuran
- Substance No.: 77/746
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.Gaukler, 6050 Offenbach
- Weight at study initiation: 3.1, 2.9, 3.6 kg for 4 h, 1 h and 3 min test respectively
- Diet: ad libitum, standard diet Sniff K, standard diet for rabbits and guinea pigs
- Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 3 min, 1 h and 4 h
- Observation period:
- 8 days
- Number of animals:
- 2 per exposure time
- Details on study design:
- TEST SITE
- Area of exposure: dorsal skin (2 x 2 cm)
- Type of wrap if used: rubber sheet, fixed with adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol or lutrol/water 1:1 w/w
- Time after start of exposure: 3 min, 1 h or 4 h
OBSERVATION TIME POINTS
- immediately after exposure, and at 1, 2, and 8 days after exposure
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 4 hour exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 4 hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 1 hour exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 1 hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 2.75
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 3 minutes
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 and 2 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 3 minutes
- Irritant / corrosive response data:
- - 3 minute test: Immediately after exposure slight erythema and edema was observed. One and two days after exposure severe erythema, strong to severe edema and necrosis was observed. After 8 days severe edema, slight erythema and necrosis was observed.
- 1 hour test: severe erythema and necrosis were observed at all time points in both animals. Immediately after exposure slight edema was observed. One and two days after exposure strong to severe edema was observed. Eight days after exposure slight edema was observed in one animal.
- 4 hour test: slight edema, severe erythema and necrosis were observed at all time points in both animals. - Other effects:
- No systemic effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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