Registration Dossier
Registration Dossier
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EC number: 225-060-7 | CAS number: 4635-87-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 2015
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Version / remarks:
- August 1998
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC No 440/2008 Part B. Acute Toxicity, Dermal Irritation/Corrosion
- Version / remarks:
- May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF)
- Version / remarks:
- November 2000, including revisions up to 2019
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pent-3-enenitrile
- EC Number:
- 225-060-7
- EC Name:
- Pent-3-enenitrile
- Cas Number:
- 4635-87-4
- Molecular formula:
- C5H7N
- IUPAC Name:
- (3E)-pent-3-enenitrile
- Details on test material:
- - Name of test material (as cited in study report): 3-Pentenenitrile
- Analytical purity: > 95 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 mL pure substance
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 21 d
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 0.3
- Max. score:
- 0.3
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 1.3
- Max. score:
- 1.3
- Reversibility:
- fully reversible within: 21 d
Applicant's summary and conclusion
- Conclusions:
- Based on these results 3-PENTENENITRILE does not have to be classified and has no
obligatory labelling requirement for skin irritation according to the Globally Harmonized
System of Classification and Labelling of Chemicals (GHS) of the United Nations (2017)
(including all amendments up to 2019) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of items and mixtures (including all amendments up to 2019)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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