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Diss Factsheets
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EC number: 248-660-0 | CAS number: 27794-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Reproduction: Based on the read across data from the key three generation reproductive study using nitrilotrimethylenetris(phosphonic acid), it is unlikely that nitrilotris(methylene)]trisphosphonic acid, potassium salt will impair fertility. (Biodynamics 1979a, rel 2).
Short description of key information:
The category hypothesis is that all the members are various ionised forms of the acid 6419-19-8. The main assumption is that potassium is not significant in respect of all the properties under consideration. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Hence some properties (measured or expressed in aqueous media) for a salt can be directly read-across (with suitable mass correction) to the parent acid and vice versa.
Read across data from a reliable three-generation reproductive toxicity feeding study in rats using nitrilotrimethylenetris(phosphonic acid) reported a general and reproductive toxicity NOAEL to be greater than the highest dose tested; (approximately equal to a dose of 275 mg/kg bw/day in males and 310 mg/kg bw/day for females). (Biodynamics Inc, 1979a)
Read across from a reliable teratology study in rats using nitrilotrimethylenetris(phosphonic acid) reported a maternal NOAEL to be 500 mg/kg bw/day, and the NOAEL for fetotoxicity and teratogenicity to be >1000 mg/kg bw/day. (Biodynamics Inc 1979b, rel 2).
Effects on developmental toxicity
Additional information
Developmental effects:
Based on the results from the key study which reporteda maternal NOAEL to be 500 mg/kg bw/day, and the NOAEL for fetotoxicity and teratogenicity to be >1000 mg/kg bw/day.(Biodynamics Inc 1979b, rel 2), together with the additional read across data from a pilot study to investigate theToxicity of FA 42902 in Pregnant Miceusing nitrilotrimethylenetris(phosphonic acid) (Biodynamics 1980, and Biodynamics 1979b respectively), it unlikely that in the absence of maternal toxicity nitrilotris(methylene)]trisphosphonic acid, potassium salt is a developmental toxicant.Justification for classification or non-classification
Based upon the read across results from the key studies, nitrilotris(methylene)]trisphosphonic acid, potassium salt is not required to be classified for reproductive or developmental effects.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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