3,3'-thiodi(propionic acid)

Guidance on Safe Use

First-aid measures

General information: In case of persisting adverse effects, consult a physician. Change contaminated, saturated clothing.

Eye irritation: Rinse with plenty of water for several minutes. If possible, remove contact lenses before rinsing. Seek immediate medical advice.

Skin: After contact with skin, wash with water. If the appearance of the skin changes, seek medical advice.

After ingestion: Do not induce vomiting. Seek medical advice immediately. Rinse mouth thoroughly with water. Never give anything by mouth to an unconscious person.

Most important Signs and Symptoms:

Contact to eye may cause severe pain, redness, deep burning, and reduced visual acuity.

Repeated contact to skin may cause redness and irritating symptomes.

Protection of rescuer: When rescue the victim, wear suitable protective equipments.

Fire-fighting measures

Suitable Extinguishing Media:

Use dry chemical, foam, carbon dioxide, dry sand or water to extinguish fire.

Unsuitable Extinguishing Media:

Do not use water in a jet. Doing so may be in danger of spreading fire.

Special Hazards:

Thermal decomposition products may include toxic oxides of carbon and sulfur. To avoid contact with poisonous fumes, operate from windward during fire

fighting.

Fire fighting procedures:

Keep persons not directly involved in fire fighting out of the area of the fire. Use dry chemicals, a CO2 extinguisher, dry sand, water spray etc. to extinguish

a fire in its early stages. In case of large fires, deprive the fire of a source of oxygen using a foam extinguisher or by other means. Wear protective equipment during fire fighting.

Accidental release measures

Person protection (Protective equipments):

Prevent entry to the contaminated area e.g. by cordoning off with a rope. To avoid in contact with poisonous fumes, operate from windward during cleaning.

Wear protective equipment.

Environment protection:

Prevent discharge of leaked product to sewerage systems or watercourses. Let evacuate a person under the lee. Collect the soaked materials into an empty

container as possible. Do not empty into drains.

Protects from secondary accidents:

Remove ignition source from the surrounding area.

Handling and storage

Handling:

If the product is to be handled indoors, provide good ventilation using a local exhaust system or other measures. Keep the product away from flames, sparks and high temperature substances. Handle the container gently; drop, strike or drag. Wear protective equipment to prevent contact with skin or eyes or inhalation of dust.

Storage:

Keep container tightly closed. Do not store in the same area with peroxides. Store in a cool (below 35°C), dark, well- ventilated place. Lock up the safekeeping place.

Recommended Material:

For containers use plastic inserted paper bag.

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

No classification currently assigned. Avoid contact with water. Do not drop.

Exposure controls / personal protection

Exposure Limits: 10mg/m³(ACGIH)

General: Where there is any possibility that an employee's eyes and/or skin may be exposed to this substance, the employer should provide any eye fountain and quick drench shower within the immediate work area for emergency use.

Ventilation: Provide local exhaust or process enclosure ventilation. Ventilation equipment should be explosion-proof if explosive concentrations of mist, vapor or fumes are present.

Eye Protection: Where there is any possibility that an employee’s eyes and/or skin may be exposed to this substance, the employer should provide any eye wash fountain and quick shower within the immediate work area for emergency use. Employee must wear safety goggles and a face-shield to prevent contact with this substance. Emergency wash facilities.

Clothing: Employee must wear appropriate protective(impervious)clothing and equipment prevents any possibility of skin contact with this substance.

Gloves: Employee must wear appropriate protective gloves to prevent contact with this substance.

Respirator: The following respirators are recommended based on information found in the physical data, toxicity and health effects section. They are ranked in order from minimum to maximum respiratory protection. The specific respirator selected must be based on contamination levels found in the work place, must be based on the specific operation, must not exceed the working limits of the respirator and must be jointly approved by the National Institute for Occupational Safety and Health and the Mine Safety and Health Administration(NIOSH-MSHA). Any dust and mist respirator. Any air-purifying respirator with a high-efficiency particulate filter. Any powered air-purifying respirator with a dust and mist filter. Any powered air-purifying respirator with high-efficiency particulate

filter. Any type ‘C’ supplied-air respirator operated in the pressure-demand or other positive pressure or continuous-flow mode. Any self-contained breathing apparatus.

For Firefighting and Other Immediately Dangerous to Life or Health Conditions:

Any self-contained breathing apparatus that has full face piece and operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirators that has a full- face piece and operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathe apparatus operated in pressure-demand or other positive-pressure mode.

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Stability and reactivity

Reactivity: Stable under normal temperatures and pressures.

Condition to Avoid: May burn but dose not ignite readily. Avoid contact with strong oxidizers, excessive heat, spark or open flame.

Incompatible Materials: Oxidizers(strong),fire and explosion hazard.

Hazardous Decomposition: Thermal decomposition products may include toxic oxides, or carbon and sulfur.

Polymerization: May undergo exothermic polymerization if exposed to sunlight or heat. If polymerization occurs in a closed container, sufficient heat and pressure may be generated to rupture the container.

Disposal considerations

Observe all federal, state and local regulations when disposing of this substance.