Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-832-2 | CAS number: 26591-72-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In order to assess the skin sensitizating potential of 3-Methyl-l-vinylimidazolium methosulfat as 46.4 % solution in water, the guinea pig Maximization Test (OECD Guideline No. 406, GLP; BASF, 1998) was carried out in female guinea pigs (5 per control group; 10 in the test group). Test item was applied not further diluted (46.4 % 3 -Methyl-1 -vinylimidazolium methosulfat content) or as 75% preparation of the stock solution (34.8 % 3 -Methyl-1 -vinylimidazolium methosulfat content) in water. This was based on the range finding test where the minimum irritant concentration was found to be the not further diluted test substance (=> 46.4 % content in water) and the maximum non-irritant concentration was found to be a 75 % preparation of the stock solution in aqua bidest (=> 34.8 % content in water).
The intradermal induction with 5% (2.32 % 3 -Methyl-1 -vinylimidazolium methosulfat content) preparations of the 46.4% stock solution caused slight to well-defined signs of skin irritation in all test group animals.
After the percutaneous induction with the not further diluted test substance, incrustation, partially open (caused by the intradermal induction) could be observed in addition to well-defined erythema and slight edema in all test group animals.
A challenge was performed 14 days after the percutaneous induction with a 75 % preparation of the stock solution (34.8% content in water).
In the main experiment, there were no skin findings in any of the animals (controls and test group) after challenge with the test item. Based on the results of this study it was concluded that 3-Methyl-l-vinylimidazolium methosulfat does not have a sensitizing effect in the Maximization Test under the test conditions chosen.
Migrated from Short description of key information:
Guinea pig maximization test (BASF AG, 1998): not sensitizing
Justification for classification or non-classification
Based on the data received from the Guinea Pig Maximization Test, no classification as skin sensitizer according to EU Directive 67/548/EEC and EU classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
