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Diss Factsheets
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EC number: 203-376-6 | CAS number: 106-23-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In the chosen key study for bacterial mutagenicity, i.e. an Ames test (Plate incorporation assay), Salmonella strains TA 97a, TA 98, TA 100, TA 102 were incubated with citronellal (1-300 µg/plate) both in the absence and presence of metabolic activation (Gomes-Carneiro 1998). No increase of revertant colonies were observed up to cytotoxic concentrations. Therefore citronellal was found to be not mutagenic in bacteria under the given testing conditions.
In the chosen key study for mutagenicity in mammalian cells, i.e. a HPRT gene mutation assay in CHO cells according to OECD TG 476 and GLP, citronellal showed no relevant dose-dependent increase in the number of mutant colonies up to cytotoxic concentrations either without S9 mix or after the addition of a metabolizing system (BASF 50M0411/074063). Thus, under the experimental conditions of this study, citronellal is considered not to be a mutagenic substance under in vitro conditions in the HPRT locus assay.
In the chosen key study for cytogenicity in mammalian cells, i.e. a MNT test in V79 cells according to OECD TG 487 and GLP, citronellal did not lead to a biologically relevant increase in the number of micronucleated cells up to cytotoxic concentrations either without S9 mix or after the addition of a metabolizing system in two experiments performed independently of each other. Thus, citronellal is considered not to have a chromosome-damaging (clastogenic) effect nor to induce numerical chromosomal aberrations (aneugenic activity) under in vitro conditions in V79 cells under the given experimental conditions (BASF 33M0411/07M024).
In a supportive study, CHO K1-cells treated with citronellal did not show any increase in mean SCE frequency compared to the negative control when tested in the absence of metabolic activation up to concentrations reaching the cytotoxicity level (333 µM; Sasaki 1989).
Overall, on the basis of the present data, citronellal is considered to have no mutagenic or clastogenic/aneugenic activity in bacteria and mammalian cells.
Short description of key information:
Salmonella typhimurium reverse mutation assay with the strains TA 97a, TA 98, TA 100 and TA 102: negative (Gomes-Carneiro 1998)
HPRT gene mutation assay in CHO cells (OECD Guideline 476, GLP): negative (BASF 50M0411/074063)
MNT in V79 cells (OECD Guideline 487, GLP): negative (BASF 33M0411/07M024)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The present data on genetic toxicity do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008 and therefore, a non-classification is warranted.
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