Disodium 2-hydroxyethyliminodi(acetate)

Endpoint summary

Description of key information

In a feeding study, EDG was readily absorbed with 85% of the ingested dose voided in the urine and <10% recovered in feces. Following dermal application, approximately 3.25% of the total radioactivity dosed was absorbed in 72 h and the excretion was primarily through urine (2.19% of absorbed amount).

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Absorption rate - oral (%):

85

Absorption rate - dermal (%):

3.25

Additional information

EDG was readily absorbed when fed through diet to CD rats at test substance concentration of 70 µmoles/g diet for 10 days. The percent of the recovered 14C-test substance present in the urine did not vary during the nine days of 24 h urine collections showing that the test substance attained equilibrium very rapidly in rats. Of the tissues assayed, the kidney had the highest concentration of 14C-test substance followed by the bone; the liver and bladder had the same14C-test substance concentration, which was greater than that of the heart. The high kidney level probably reflected entrapment of urine in the kidney. The high bone concentration of test substance was expected since compounds that form complexes with divalent metals accumulate in bone. The bladder attained a test substance concentration similar to that in the liver. The test substance did not accumulate in blood cells, nor did it bind to plasma proteins to an appreciable extent; the plasma ultrafiltrate contained approx. 90% of the plasma total test substance. EDG-Na2 induced morphological and histological changes in kidney.

When radiolabeled EDG was applied to the backs of SD male rats as a 10% aqueous solution at pH 10.5 (62 mg/kg), approximately 3.25% of the total radioactivity dosed was absorbed in 72 h and the excretion was primarily through urine (2.19% of absorbed amount). The tissue distribution was low (≤0.16 µg/g).