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Diss Factsheets
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EC number: 423-340-5 | CAS number: 162881-26-7 CGI 819
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The test substance was investigated for bacterial mutagenicity in the in vitro Ames test according to the OECD TG 471 (1987) and under GLP compliance. The following strains were used: S. typhimurium TA98, TA 100, TA 102, TA 1535, TA 1537 and E. coli WP2 uvrA; the test was conducted in absence and presence of S9-mix (Ciba-Geigy Ltd 1996b). Under the experimental conditions used, the test substance was not mutagenic to bacteria.
The test substance was investigated for clastogenicity in the in vitro mammalian chromosome aberration test according to the OECD TG 473 (1983) and GLP compliance using isolated peripheral lymphocytes. Under the experimental conditions used, the test substance was not clastogenic (NOTOX 1997).
The test substance was investigated for mutagenicity in mammalian cells in the in vitro Mouse Lymphoma Assay according to the OECD TG 476 (1997) and GLP compliance. Under the experimental conditions used, the test substance did not induce mutations (RCC 2006).
No in vivo studies are available . However, owing to the REACH data requirements needed for Tier 2 Substances (100 to 1000 t/a) and since in vitro studies (mutagenicity in bacteria, cytogenicity, mutagenicity in mammalian cells) are available which all were negative, no further in vivo studies are needed.
Short description of key information:
Three in-vitro genotoxicity tests were performed to study the mutagenic and clastogenic potential of the substance with and without metabolic activation. None of the test could induce a positive result. The conduct of an in-vivo mutagenicity test can be omitted based on the unequivocal outcome of the in-vitro tests.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
An in vitro bacteria mutagenicity test (Ames test, OECD 471), an in vitro cytogenicity test (chromosome aberration assay (OECD 473) and an in vitro gene mutation assay in mammalian cells (OECD 476) are available for the test substance. These studies revealed that it is neither clastogenic nor mutagenic to bacteria and to mammalian cells. On the basis of the available data, there is no need to classify the substance according to the EU 67/548/EEC Directive and there is no need to classify the substance according to the European GHS Regulation (EC) No. 1272/2008 (referred to as CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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