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Diss Factsheets
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EC number: 216-403-1 | CAS number: 1575-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Version / remarks:
- - FIFRA Guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1150 (Acute inhalation toxicity)
- Version / remarks:
- - TSCA Guideline 40CFR
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-chlorovaleryl chloride
- EC Number:
- 216-403-1
- EC Name:
- 5-chlorovaleryl chloride
- Cas Number:
- 1575-61-7
- Molecular formula:
- C5H8Cl2O
- IUPAC Name:
- 5-chloropentanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): 5-Chloropentanoyl chloride
- Physical state: colourless liquid
- Storage conditions: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Boehringer Ingelheim Pharma KG, FRG
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: Male 257.0 - 285.8 g, Female 162.1 - 206.7 g
- Housing: singly housing, in type DK III cages (Becker, Germany) without bedding
- Diet: ad libitum, KLIBA rat/mouse/hamster laboratory diet 10 mm pellets (Provimi Kliba SA, Kaiseraugst, Switzerland)
- Water: ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air: fully air-conditioned
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: IKA 02 (glass-steel construction)
- Exposure chamber volume: 200 L
- Method of holding animals in test chamber: animals were kept singly in compartmentalized wire cages, and were exposed in the chamber.
- Technical equipment, test group 1: continuous infusion pump Perfusor VII (B. Braun), vaporizer with thermostat (glass), aerosol mixing vessel (glass).
- Techinical equipment, test group 2: glass generator with sintered glass disk (pore - size 90-150 µm), glass tube with quartz wool plug to prevent aerosol transfer to the inhalation chamber.
- Procedure, test group 1: The vapor was generated by supplying 1.8 mL/h of the test substance to the heated vaporizer by means of the continuous infusion pump. The vapors that developed were taken up by the supply air and passed into the exposure system. During exposure no total evaporation of the test substance in the generator was achieved and the panes of the chamber steamed up.
- Procedure, test group 2: The test substance was introduced into a glass generator above a sintered glass disk and vapors were generated by bubbling air through the substance column. The mass of the generator was determined before and after exposure for calculation of the substance flow. During exposure the panes of the chamber steamed up.
- Exposure: the exposure system was located inside an exhaust cabin in an air-conditioned laboratory. The about 3 or 7% higher amounts of exhaust air, which were adjusted by means of a separate exhaust air system, achieved a slightly negative pressures inside the exposure systems. This ensured that no contamination of the laboratory occurred as result of possible leakage from the inhalation chambers. The supply and exhaust air flows were adjusted and continously measured with flowmeters (Rota).
- Rate of air: An air changes of 15 times per hour can be calculated by dividing the supply air flows by the volume of the inhalation system.
- Supply air: 3000 L/h
- The temperatures in the inhalation systems were measured continously with a digital thermometer.
TEST ATMOSPHERE
- Brief description of analytical method used: Samples were taken with a 4 mm sampling probe, 2 absorption vessels and a fritted glass flask connected in series and filled with sorption solvent (2-Propanole). Sampling was done with a flow of 1 L/min, velocity of 1.25 m/s. 4 samples per concentration group in about hourly invervals were taken. With a gas chromatographic method (GC HP 5840 A, Hewlett Packard) the concentration of the test atmoshpere was measured.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- using a gas chromatographic method (GC HP 5840 A, Hewlett Packard)
- Duration of exposure:
- 4 h
- Remarks on duration:
- plus 20 min of equilibration time
- Concentrations:
- Test group 1: 0.27 mg/L
Test group 2: 0.32 mg/L - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The body weight of the animals was determined just prior to exposure, after 7 days and at the end of the observation period. A check for overt clinical signs of toxicity or mortality as well as a check for the presence of feed and drinking water was made twice a day on workdays and once daily on weekends and public holidays. Detailed clinical observations were recorded for each animal separately several times during exposure and at least once on each workday in the observation period.
- Necropsy of survivors performed: yes - Statistics:
- The statistical evaluation of the concentration-response relationship was carried out using a computer program: Depending on the data of the concentration-response relationship obtained by way of experiment, this program is used to estimate the LC50 or to perform a Probit analysis. Estimation of the LC50 will produce types " LC50 greater than", " LC50 approx .", or " LC50 smaller than" . If the results are type "LC50 greater than" or "LC50 smaller than", an additional binomial test is carried out, in order to verify these statements statistically .
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.32 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed in all exposed animals.
- Clinical signs:
- other: - Irregular respiration was observed in 1 out of 5 male animals exposed to 0.27 mg/L, until 1 hour after start exposure. - No clinical signs were observed female animals exposed to 0.27 mg/L. - Irregular respiration, accelerated respiration, eyelid closur
- Body weight:
- Mean body weight start study
- 0.27 mg/L: Male 262 g; Female 194 g
- 0.32 mg/L: Male 274 g; Female 187 g
Mean body after 14 days
- 0.27 mg/L: Male 330 g; Female 223 g
- 0.32 mg/L: Male 335 g; Female 220 g - Gross pathology:
- No gross pathological abnormalities were detected in all exposed animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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