Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-378-7 | CAS number: 1569-69-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP. Examinations were terminated after 72 hours instead of 14 days, and no information on reversibility is available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexanethiol
- EC Number:
- 216-378-7
- EC Name:
- Cyclohexanethiol
- Cas Number:
- 1569-69-3
- Molecular formula:
- C6H12S
- IUPAC Name:
- cyclohexanethiol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material: Cyclohexyl Mercaptan
No other information reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Standard laboratory rabbit cage
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: 4 shaved sites per animal, 2 of which abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: Undiluted - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 4 sites, each approx. 2 inch square
- Type of wrap if used: gauze patch secured with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing: Mild soap solution
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize (1959)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 5.14
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin
- Irritant / corrosive response data:
- Individual scores are not presented in the study report therefore it is not possible to fully assess the results according to the criteria of Regulation (EC) No 1272/2008. However based on the severe erythema and moderate to severe oedema reported for intact skin, it can be concluded that the substance is irritating to skin. Since examinations were terminated after 72 hours, no information on reversibility is available.
- Other effects:
- Severe bleaching of the skin was reported at all exposure sites but there is no indication that necrosis was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a skin irritation test in which the protocol resembled OECD 404, cyclohexylmercaptan was found to be irritating to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
