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EC number: 205-154-4 | CAS number: 134-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study the LD50 was determined to be 189 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 189 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Five Wistar rats per sex per dose were exposed, in a acute oral toxicity study similar to OECD guideline 401, to 68.1, 100, 147.0, 215, 316, and 464 mg/kg bw of the test substance, dissolved in water, via oral gavage (BASF 1986). After an observation period of 14 days the surviving animals were necropsied. Several clinical signs were observed such as dyspnea, apathy, excitation, abnormal position, staggering, tremors, twitching, tonus of the jaws, tonic convulsions, piloerection, exophthalmos, salivation, imbalance, and a poor general state. These effects were absent after 2 days. Upon necropsy edematous lungs and focal hyperemia were observed in animals that died. The LD50 was determined to be 189 and more than 464 mg/kg bw for females en males, respectively.
In the second study (NTP 1986, rats) Fischer 344/N rats were exposed to 75, 150, 300, 600, and 1200 mg/kg bw. Hyperkinesia that progressed to convulsive seizure, ataxia, and lethargy were observed in animals that died. Pathology showed mild portal-hepatic congestion, mild pulmonary congestion, and epistaxis. The LD50 was determined to be between 75 and 150 mg/kg bw. In the third study (NTP 1986, mice) B6C3F1 mice were exposed to 125, 250, 500, 1000, 2000 mg/kg bw. Hyperkinesia that progressed to convulsive seizure, ataxia, and lethargy were observed in animals that died. Pathology showed mild portal-hepatic congestion, mild pulmonary congestion, and epistaxis. The LD50 was determined to be 812 and 1072 mg/kg bw for males and females, respectively.
Justification for selection of acute toxicity – oral endpoint
Three acute oral toxicity studies are available, performed in two species. The study was chosen in which the most sensitive species was used (rat) and surviving animals were necropsied at the end of the study.
Justification for classification or non-classification
Based on an oral LD50 of 189 mg/kg bw bis[[R-(R*,S*)]-β-hydroxy-α-methylphenethyl)methylammonium] sulphate has to be classified for Acute toxicity Cat 3: H301: Toxic if swallowed in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and T: R25: Toxic if swallowed in accordance with Directive 67/548/EEC (DSD).
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