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Diss Factsheets
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EC number: 233-953-8 | CAS number: 10466-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not given
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published paper with little experimental detail. But data appears to be scientifically acceptable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacology and toxicology of potassium perrhenate and rhenium trichloride
- Author:
- Haley T.J. and Cartwright F.D.
- Year:
- 1 968
- Bibliographic source:
- Journal of Pharmaceutical Sciences Vol 57 (No. 2), 321-323
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: Draize J.H. et al. (1944). J. Pharmacol. Exptl. Therap. 82, 377
- Principles of method if other than guideline:
- The method of Draize et al. (1944) was used to study eye irritation in rabbits. 3 mg of material applied to one eye in each of two rabbits and assessed for irritation.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium perrhenate
- EC Number:
- 233-953-8
- EC Name:
- Potassium perrhenate
- Cas Number:
- 10466-65-6
- Molecular formula:
- K.O4Re
- IUPAC Name:
- Potassium oxido(trioxo)rhenium
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Potassium perrhenate
- Physical state: Crystalline solid
- Analytical purity: Minimum 99.9%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 3 mg - Duration of treatment / exposure:
- Readings are made generally at 1, 24 and 48 hours after instillation of test material according to Draize. The published paper indicates that readins were made up to 72 hours. Material is not removed from the eye following instillation.
- Observation period (in vivo):
- Generally up to 48 hours according to Draize. Readings can be made after 96 hours if residual injury is present. The published paper indicates that readins were made up to 72 hours.
- Number of animals or in vitro replicates:
- Two
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Not irritating
- Remarks on result:
- other: No detectable damage to the cornea, iris, or conjunctiva
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Presumably based on Draize scores
- Conclusions:
- Potassium perrhenate, when applied to one eye of each of two rabbits, was described as causing no detectable damage to the cornea, iris, or conjunctiva throughout the 72-hr observation period.
- Executive summary:
A brief published paper describes an eye irritation study in rabbits using the method of Draize et al. (1944). Potassium perrhenate (3 mg) was applied (presumably as a crystalline solid) to one eye of each of two rabbits. The untreated eye served as the control. No detectable damage to the cornea, iris, or conjunctiva was reported during an observation period of 72 hours.
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