Registration Dossier
Registration Dossier
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EC number: 202-086-7 | CAS number: 91-64-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Miller, L.C., and Tainter, M.L.: Proc.Soc. Exper.Biol. Med., 57:261.1944
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: albino carworth
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Remarks:
- also corn oil
- Control animals:
- yes
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 290 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: Dose of coumarin(10% in Propylene Glycol)
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 520 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: Dose of coumarin(6% in corn oil)
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Reference
Acute toxicity in fasted male albino rats following single oral doses of coumarin in propylene
glycol or corn oil
Rat Groups (10 rats/group 90 grams average body wt) |
Dose of Coumarin(10% in Propylene Glycol) |
%Mortality (at 72hr) |
Dose of Coumarin(10% in corn oil) |
%Mortality (at 72hr) |
Ⅰ Ⅱ Ⅲ Ⅳ Ⅴ Ⅵ Ⅶ |
gm./kgm 0.10 0.20 0.30 0.50 0.70 1.00 1.50 |
0.0 0.0 60.0 100.0 100.0 100.0 100.0 |
gm./kgm 0.25 0.30 0.50 0.60 0.70 0.80 1.00 |
0.0 10.0 40.0 60.0 90.0 70.0 100.0 |
LD50±SD1….. Slope Factor2…. |
|
0.29±0.03gm/kgm 0.16 gm./kgm |
|
0.52±0.03 gm/kgm 0.31 gm./kgm |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 520 mg/kg bw
- Quality of whole database:
- reliable because all data come from RIFM database.
Additional information
oral.002 provided more information.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
