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EC number: 402-810-3 | CAS number: 17980-47-1 DYNASILAN BH N; DYNASILAN BSM 100 N; DYNASILAN NH 42
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two in vitro bacterial mutagenicity studies are available for the test substance. In the key study (Huls 1992), no evidence for mutagenicity to bacteria was observed in any of the strains tested. Negative results were also obtained with all strains tested, both with and without activation, in a supporting study (Schöberl 1989).
In vitro cytogenicity and mutagenicity studies in mammalian cells are also available (May 1992 and Ebert 1991, respectively). Both of these studies gave negative results and the test substance was judged to be non-genotoxic in mammalian cells.
Two in vivo studies are available. In the key study ( Huntingdon Research Centre 1988c), negative results were obtained in a mouse micronucleus study. A more recent mouse micronucleus study, for which only a summary report was available, also gave a negative result (Worksafe Toxicology Lab, 1994).
The key studies were selected on the basis of reliability and most recent reports.
Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test) (Schöberl 1989, Huls 1992; rel 2): negative with and without activation in all strains tested (OECD TG 471 1982).
Cytogenicity in mammalian cells (May 1992; rel 2): negative in Chinese hamster lung fibroblasts (V79) (OECD TG 473).
Mutagenicity in mammalian cells (Ebert 1991; rel 2): negative in CHO cells (OECD TG 476).
In vivo:
Single oral exposure to 8800 mg/kg bw in mouse. Micronucleus assay negative for chromosomal aberration (Huntingdon Research Centre 1988c; rel 1) (OECD TG 474).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available information for triethoxyisobutylsilane (CAS 17980 -47 -1) indicates that it is not mutagenic to bacteria and it is not cytogenic or mutagenic to mammalian cells. In addition, there is no evidence for the induction of micronuclei in vivo. It is therefore considered that classification for mutagenicity is not required in accordance with current regulation (EC 1272/2008).
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