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Diss Factsheets
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EC number: 200-876-6 | CAS number: 75-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- circa 1955
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- publication
- Title:
- Observations on the Toxicity of Nitromethane.
- Author:
- Weatherby, J.H
- Year:
- 1 955
- Bibliographic source:
- AMA Archives of Industrial Health, 11, 102-106.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The purpose of the study was to investigate changes in the animals which might result from the administration of NM in quantities which would prove fatal in a period of several hours.
Animals were given nitromethane in doses of 200 mg/kg every 10 minutes via IV on a pre-set dosing regimen. Once treated, the animals were observed until death or sacrifice. - GLP compliance:
- no
Test material
- Reference substance name:
- Nitromethane
- EC Number:
- 200-876-6
- EC Name:
- Nitromethane
- Cas Number:
- 75-52-5
- Molecular formula:
- CH3NO2
- IUPAC Name:
- nitromethane
- Details on test material:
- No additional information available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 0.3% methylecellulose solution
- Doses:
- The test material was administered as a 20% emulsion, with 0.3% methylcellulose aas the emulsifying agent.
4000 cps methylcellulose
2000 mg/kg
1350 mg/kg
1000 mg/kg
50 cps methylcellulose
1500 mg/kg
1250 mg/kg
1000 mg/kg
800 mg/kg - No. of animals per sex per dose:
- Dose No. animals
4000 cps methylcellulose
2000 mg/kg 3
1350 mg/kg 2
1000 mg/kg 2
50 cps methylcellulose
1500 mg/kg 2
1250 mg/kg 2
1000 mg/kg 4
800 mg/kg 5 - Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
IV
toxicity of NM was somewhat dependent on the viscosity of the dosing
solution (more viscous was less toxic). In
most cases, the animals that were fatally poisoned died 8-18 hours after
administration.
4000 cps methylcellulose
2000 mg/kg 0/3
survived
1350 mg/kg 0/2
survived
1000 mg/kg 2/2
survived
50 cps methylcellulose
1500 mg/kg 0/2
survived
1250 mg/kg 0/2
survived
1000 mg/kg 0/4
survived
800 mg/kg 2/5
survived
Applicant's summary and conclusion
- Conclusions:
- The intravenous LD50 in rabbits for nitromethane was >1000 mg/kg when administered as a 20% emulsion with 0.3% methylcellulose (4000 cps) as the emulsifying agent.
The intravenous LD50 in rabbits for nitromethane was ~800 mg/kg when administered as a 20% emulsion with 0.3% methylcellulose (50 cps) as the emulsifying agent. - Executive summary:
The acute toxicity of nitromethane via the intravenous route was examined.
The intravenous LD50 in rabbits for nitromethane was >1000 mg/kg when administered as a 20% emulsion with 0.3% methylcellulose (4000 cps) as the emulsifying agent.
The intravenous LD50 in rabbits for nitromethane was ~800 mg/kg when administered as a 20% emulsion with 0.3% methylcellulose (50 cps) as the emulsifying agent.
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