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EC number: 221-254-0 | CAS number: 3047-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 April 1998 to 30th April 1998.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-ethyloxetane-3-methanol
- EC Number:
- 221-254-0
- EC Name:
- 3-ethyloxetane-3-methanol
- Cas Number:
- 3047-32-3
- Molecular formula:
- C6H12O2
- IUPAC Name:
- (3-ethyloxetan-3-yl)methanol
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): TMP oxetane
- Physical state: Colourless liquid.
- Analytical purity: No information provided.
- Purity test date: No information provided.
- Lot/batch No.: JNS 980121 F 1-3
- Expiration date of the lot/batch: No information provided.
- Storage condition of test material: Stored in a refrigerator at 2 - 8°C in the dark.
Test animals
- Species:
- rabbit
- Strain:
- other: SPF albino rabbits of the stock Mol:Russian.
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding and Research Centre A/S. Ejby, DK-4623, Lille Skensved.
- Age at study initiation: No information provided.
- Weight at study initiation: 2.5 - 2.6kg
- Housing: The animals were housed individually in PPO/HIPS cages with a perforated floor and floor area of 2576cm2.
- Diet (e.g. ad libitum): A pelleted complete rabbit diet "Altromin 2123" available ad libitum.
- Water (e.g. ad libitum): Free access to bottles with domestic quality drinking water acidified with hydrochloric acid to pH 2.5 to prevent microbial growth.
- Acclimation period: At least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3°C
- Humidity (%): 55 ± 15%
- Air changes (per hr): 10 air changes per hour.
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark.
IN-LIFE DATES: From: To: No information provided.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL - Duration of treatment / exposure:
- 4 hours exposure.
- Observation period:
- Observation period was 72 hours, with readings made at 24, 48 and 72 hours after exposure.
- Number of animals:
- Three animals.
- Details on study design:
- TEST SITE
- Area of exposure: Four shaved areas (2.5cm x 2.5cm) on the backs of the rabbits. The test material was applied to 2 sites, one on the left posterior and one on the right posterior.
- Type of wrap if used: Test material was applied to gauze patches which were applied to the shaved areas and secured with 2.5cm wide adhesive tape and fixed with Scanpor tape (5cm wide). Nobifix (6cm width) was then loosely wound round the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Following the 4 hour exposure period, the treated skin was cleaned with lukewarm water.
- Time after start of exposure: 4 hours after start of exposure.
SCORING SYSTEM: Readings made according to numerical scale.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: Only the scores from the 3 readings (24, 48, 72 hours) are included in the calculation of the individual values.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: Only the scores from the 3 readings (24, 48, 72 hours) are included in the calculation of the individual values.
- Irritant / corrosive response data:
- Very slight erythema was observed in two animals 1 hour from termination of exposure. Apart from that, no erythema was observed in any of the animals at the other observations. No oedema was observed in any of the animals at any of the observations.
- Other effects:
- No information provided.
Any other information on results incl. tables
Individual scores and mean values:
Rabbit No./Weight (kg) |
Site |
Erythema-Eschar observed at hours |
Individual mean values* |
Oedema observed at hours |
Individual mean values* |
||||||
1 |
24 |
48 |
72 |
1 |
24 |
48 |
72 |
||||
1116/2.5 |
LP |
0 |
0 |
0 |
0 |
0.0 |
0 |
0 |
0 |
0 |
0.0 |
|
RP |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
2888/2.5 |
LP |
1 |
0 |
0 |
0 |
0.0 |
0 |
0 |
0 |
0 |
0.0 |
|
RP |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
2102/2.6 |
LP |
1 |
0 |
0 |
0 |
0.0 |
0 |
0 |
0 |
0 |
0.0 |
|
RP |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
LP: Left posterior test field
RP: Right posterior test field.
* Only the scores from the 3 readings (24, 48, 72 hours) are included in the calculation of the individual values.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, TMP oxetane was not found to be irritating to skin and does not meet the criteria for classification for skin irritation.
- Executive summary:
The primary skin irritant effect of TMP oxetane was investigated in accordance with OECD Guideline 404 and EEC Guideline B.4. Three rabbits were exposed to the test article at 2 skin sites on the back, under an occlusive dressing. After 4 hours of exposure, the patches and tape were removed and the skin washed to remove test article with lukewarm water. Skin was examined at 1, 24, 48 and 72 hours after termination of exposure. No skin reactions or only very slight skin reactions were observed in all three animals from 1 to 72 hours after the termination of exposure. Under the experimental conditions described in the report, the mean score for erythema was 0.0 and for oedema was 0.0. Under the conditions of this study, TMP oxetane was not found to be irritating to skin.
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