Registration Dossier
Registration Dossier
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EC number: 272-727-3 | CAS number: 68909-99-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. For read across justification please refer to IUCLID chapter 13.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107, (1962)
- GLP compliance:
- no
- Test type:
- other: Inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- N-(2-aminoethyl)-1,3-propanediamine
- EC Number:
- 236-882-0
- EC Name:
- N-(2-aminoethyl)-1,3-propanediamine
- Cas Number:
- 13531-52-7
- Molecular formula:
- C5H15N3
- IUPAC Name:
- N1-(2-Aminoethyl)-1,3-propanediamine
- Details on test material:
- - Name of test material (as cited in study report): N-Mono(aminopropyl)1,2-diaminoaethan (N-3-Amin)
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 226 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 1 days
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Remarks:
- calculated saturated vapour concentration
- Effect level:
- > 0.3 mg/L air
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: attempt to escape, closure eyelid, eye irritation
- Body weight:
- No adverse effects observed
- Gross pathology:
- Nothing abnormal detected.
Any other information on results incl. tables
-
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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