Registration Dossier
Registration Dossier
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EC number: 233-153-9 | CAS number: 10045-95-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Additional information
One study has been identified where neodymium (III) nitrate was assessed for its embryotoxic potential by the embryonic stem cell test (EST) (Chen et al., 2010). Three end-points were analyzed. The cytotoxicity of the compound on E14 cells and 3T3 cells (IC50 3T3, IC50 ES) were determined by MTT assay, and the inhibition of cardiomyocyte differentiation of embryonic stem cells (ID50) was determined by microscopic observation on day 10. Neodymium (III) nitrate hexahydrate was concluded to possess weak embryotoxicity. However this study as stand-alone is not adequate to support the hazard classification. In addition, no NOAEL or other dose-response information required for risk assessment purposes is provided by such a test. Therefore, this study is not considered as key study.
Justification for classification or non-classification
No reliable information is available to classify for toxicity to reproduction under CLP or DSD.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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