Registration Dossier
Registration Dossier
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EC number: 270-096-9 | CAS number: 68411-04-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study conducted according to scientifically accepted method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 10 female Wistar rats were dosed by gavage with a single dose of C.I. Direct Blue 264. Animals were observed for 14 days and number of death and alive animals were recorded.
- GLP compliance:
- no
- Test type:
- other: Limit test
- Limit test:
- yes
Test material
- Reference substance name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- EC Number:
- 270-096-9
- EC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- Cas Number:
- 68411-04-1
- Molecular formula:
- [C32H16CuN8][O3S]n[C5H12N2O2S]m
- IUPAC Name:
- Copper, [29H,31H-phthalocyaninato(2-)-.kappa.N29,.kappa.N30,.kappa.N31,.kappa.N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs.
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Doses:
- 5
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Single dose of 5000 mg/kg bw was used. 2/10 animals died during the 14 day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- In a limited early acute oral toxicity study in female rats. 2/10 animals died during the 14 days observation period, consequently the oral LD50 is above 5000 mg/kg bw.
- Executive summary:
In a limited early acute oral toxicity study in female rats. 2/10 animals died during the 14 days observation period, consequently the oral LD50 is above 5000 mg/kg bw.
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